JAMA Neurology

📄 This case report describes an optic embolism in a 30-year-old woman with sudden, painless vision loss in the left eye.

Optic Embolism in a 30-Year-Old Woman This case report describes an optic embolism in a 30-year-old woman with sudden, painless vision loss in the left eye.

Among pregnant patients with chronic , early pregnancy exposure to anti- calcitonin gene-related peptide monoclonal antibodies was associated with higher risk of clinically detected spontaneous abortion vs nonuse. Early pregnancy use of propranolol was not associated with increased risk.

🎙️ In the latest episode of the JAMA Neurology Author Interviews podcast, Anick Bérard, PhD, and Cynthia Armand, MD, discussed how these findings may inform treatment decisions for patients who become pregnant while using preventive migraine therapy.

🎧 Listen now:

Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk Interview with Anick Bérard, PhD, author of Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk. Hosted by Cynthia Armand, MD.

Among pregnant individuals with , early pregnancy exposure to anti-calcitonin gene-related peptide monoclonal antibodies was associated with a higher risk of spontaneous abortion vs no exposure, while propranolol was not associated with increased risk.

These findings inform treatment counseling for individuals of childbearing potential who are considering preventive migraine therapy.

https://ja.ma/4rXFSQR

📄 Meta-analysis: incidence was estimated at 9.7 per 1000 person-years globally, corresponding to approximately 11.4 million new cases in 2023.

Incidence was higher in women than men and higher in low- and middle-income countries vs high-income countries, providing a benchmark to inform prevention, diagnosis, and memory-care service planning.

https://ja.ma/4igZImA

Among adults screened for preclinical , plasma phosphorylated tau 217 percentage was lower in Asian, Black, and Hispanic participants than in White and non-Hispanic participants.

Apolipoprotein E ε4 carrier status was associated with higher plasma phosphorylated tau 217 percentage across groups, indicating that group-level variation may affect plasma-based screening eligibility in prevention trials.

https://ja.ma/4jRQYEM

Among patients with relapsing , earlier and continuous ocrelizumab treatment was associated with better long-term relapse and disability control than delayed initiation after interferon beta-1a.

https://ja.ma/4hEJkML

Among pediatric inpatients with unexplained presentations, rapid diagnosed nearly half of patients and changed management in about 2-thirds of diagnosed cases.

https://ja.ma/4B01IqG

Among patients with relapsing , continuous treatment with ocrelizumab over 10 years was associated with sustained suppression of relapse activity, low disability accrual, and robust control of progression independent of relapses.

Patients who started ocrelizumab earlier had better long-term disability outcomes than those who began with interferon beta-1a and switched 2 years later, supporting early use of high-efficacy treatment.

https://ja.ma/4dqqfv8

Among patients evaluated for cognitive symptoms in a memory clinic, earlier disclosure of blood-based biomarkers for pathology and neurodegeneration increased etiologic diagnostic certainty and was associated with earlier, more targeted clinical management.

Earlier disclosure was also associated with more planned discharge to primary care and fewer planned follow-up neuropsychological reassessments.

https://ja.ma/479fvxF