AsisChem

AsisChem launches new eCommerce site. Stay up to date with the latest featured compounds by signing up for your own account. www.asischem.com

Looking for the next step in fluorescent technologies? With L-ANAP you can fluorescently label any protein with a single codon substitution. Genetically encoded, L-ANAP also functions as a small molecule FRET donor.

It has been used successfully in Xenopus oocytes as well as various mammalian cell lines, and, of course, in yeast.

Take a look at the link below or email [email protected] for more information.

http://www.asischem.com/ProductCart.aspx?catnum=ASIS-0146

This week in Chemistry, from Compound Interest.

This Week in Chemistry: Alkali metal explosions explained, and 'uncooking' eggs: http://goo.gl/dJDtDc

Compound E is a potent gamma secretase inhibitor often used in Alzheimer research studies. AsisChem is proud to be offering this compound in our expanded product catalog from 1mg to 250mg quantities. Large volumes are available as custom requests.

www.asischem.com/ProductCart.aspx?catnum=ASIS-0149

AsisChem is excited to announce the release of our new website, designed with a fresh new look and user-friendly navigation, updated with the latest information about our products and services. The updated product pages contain information about existing and new products. You can now find detailed information about the company and what we are developing to support the needs of our broad range of customers. Please take a moment and visit us at www.asischem.com and tell us about your experience. We look forward to hearing from you.
Unlocking the promise of Unnatural Amino Acids
asischem.com
AsisChem is dedicated to delivering New Products and Advancements in the field of medicinal chemistry. For example, we have recently focused our efforts on developing families of unnatural amino acids, including L-ANAP derivatives - fluorescent.
Please call us to learn more.

Phone: 617.837.2114

A new ‘strategic vision’ for synthetic biology has laid out the steps Europe needs to take in the next five to 10 year to nurture the field, with chemistry a key part of its strategy. Read more: http://www.rsc.org/chemistryworld/2014/05/synthetic-biology-vision-europe-unveiled-erasynbio

Researchers have discovered a new class of proteins capable of blocking HIV particles from penetrating T-cells. The proteins, called cnidarins, were found in a feathery coral collected in waters off Australia's northern coast. Researchers screened thousands of natural product extracts and zeroed in on cnidarins which they tested on lab strains of HIV, discovering that cnidarins bind to the virus particles and prevent them from fusing with T-cell membranes. The next step is to refine methods for generating cnidarins in larger quantities so the proteins and interactions can be tested further.
The findings were presented April 29 at the Experimental Biology 2014 meeting in San Diego, California.
Read more: http://bit.ly/1hdlCPr

Pictured: False-colored SEM of HIV-1 particles co-cultivated with lymphocytes. HIV-1 virions (green) are seen on the surface of the lymphocyte and its extended pseudopodia (red/pink).
Image credit: CDC - National Center for HIV, STD and TB Prevention

AsisChem has perfected the synthesis of L-ANAP derivatives (environment-sensitive fluorescent unnatural amino acids), bipyridylalanine (Bpy-Ala,metal-binding amino acid) and others.
Ordering is easy. Just use our online catalog below.
Or feel free to call us at 1-866-609-8657

L-ANAP, (L)-3-(6-acetylnaphtalen-2-ylamino)-2-aminopropanonic acid, is an environment-sensitive fluorescent Unnatural Amino Acid (UAA). It has been demonstrated to be a useful in vitro and in vivo reporter tool for studies on protein structure, function and localization [1-4]. L-ANAP, an analogue of Prodan, can be incorporated into recombinant proteins. The ability to selectively label proteins with fluorescent probes has greatly facilitated the study of protein structure and function both in vitro and in vivo [3,6]. Current methods such as fusion proteins, protein fluorescent tagging and UAA insertion all suffer from site selectivity limitation (C- or N-terminal fusions), structural and/or functional interference from steric hindrance, and poor expression efficiency in mammalian cell lines. In contrast, L-ANAP holds significant promise for the study of protein structure and function because of its unique set of physicochemical, spectral and biocompatibility properties:

Learn how AsisChem has perfected the development of some families of unnatural amino acids: L-ANAP derivatives - fluorescent amino acids; Bipyridylalanine (BPY, BpyAla) - metal-binding amino acids and others.
http://www.asischem.com/lanap.aspx