OPO Startups
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OPO Startups is a place where entrepreneurs can connect, work and collaborate. OPO is a co-working center for digital Startups.
Located in the newly renovated “Old Post Office” building, the 10,000 square foot facility provides regional startups with affordable workspace and access to mentors, potential investors, programming, educational resources and a community of local entrepreneurs.
04/29/2026
Our next Tech Talk is Wednesday, May 13th with Gary Kellmann, CEO and Managing Partner of zPods. He will lead a discussion on OpenClaw, an AI platform for building and automating real-world workflows. The event is free and all experience levels welcome!
Date: Wednesday, May 13th
Time: 5:00 - 7:00 pm
Location: OPO Startups (119 S Main St)
RSVP: www.confluencetechhub.com/techtalks
04/15/2026
Join us next week for a Tech Talk on how to integrate AI into your business!
Meet your speaker for the upcoming Tech Talk!
Jim Gera, CEO & Co-Founder of Harmonic Health, has spent the last few years doing what most businesses are still trying to figure out: actually integrating AI into everyday operations.
On April 22, he’s bringing that experience to OPO Startups in Saint Charles for a Tech Talk. He’ll share what worked, what didn’t, and how to get your team to truly adopt AI tools.
Free to attend. RSVP here:
https://confluencetechhub.com/techtalks
01/07/2026
We are thrilled to announce Randy Schilling of OPO Startups as one of the newest members of our Board of Directors.
Randy is a long-time supporter of the EDC and is a local champion for small businesses, entrepreneurs, and STEM education. In 2021, he launched the Randy Schilling STEM Educators Grant with the EDC. In 2024, he furthered that commitment by announcing a 10-year, $100,000 endowment to fund the program.
Welcome, Randy!
11/23/2025
11/05/2025
Exciting news! The finalists for this year’s Demo Day were just announced!
These startups are doing incredible things in AI and tech, and we can’t wait to see them pitch live at OPO Startups.
Join us for Demo Day! RSVP here:
👉 confluencetechhub.com/demodayevent
10/22/2025
*LAST CALL!* All Demo Day applications are due by midnight tonight!
Don’t miss your chance to pitch your startup for a chance to win cash, and put your startup on the map in St. Charles County.
Apply now: www.confluencetechhub.com/demodayapplication
09/05/2025
What an incredible night on Historic Main Street! Supper Club 2025 brought the community together for amazing food, local partnerships, and an unforgettable celebration. Huge thanks to St. Charles Main Street Foundation for putting on such a special event that continues to make our Main Street shine. We’re already looking forward to next year!
08/26/2025
Let's help support our local Main Street with their raffle fundraiser! St. Charles Main Street Foundation is hosting a raffle full of one of a kind baskets and experiences from right here on Main Street. Get your tickets! https://stcmain.org/raffle
08/25/2025
Reminder: Tomorrow’s Tech Talk is one you won’t want to miss!
Join us Tuesday at 5 PM at OPO Startups for a Tech Talk with Ryan O’Neil, Founder & CEO of Curate. He’ll show how AI can streamline sales workflows, boost conversions, and free your team to focus on what matters.
Whether you're in sales, marketing, or tech, this one's for you!
RSVP Now: https://confluencetechhub.com/techtalks
08/21/2025
2025 Demo Day Applications are now open!
The 2025 Demo Day applications are now open!
Think you’ve got the next big idea? Apply to pitch at Demo Day and compete for cash, exposure, and connections. Applications close October 22.
More details: www.confluencetechhub.com/demodayapplication
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Address
119 S Main Street
St. Charles, MO
63301
Opening Hours
| Monday | 8am - 4pm |
| Tuesday | 8am - 4pm |
| Wednesday | 8am - 4pm |
| Thursday | 8am - 4pm |