UCSB Kosik Lab
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Molecular and Cellular Neurobiology Research
Our work focuses on neuroplasticity, which is the brain's ability to change neural connections and behavior in response to new information, sensory stimulation, development, damage, or dysfunction. We examine the molecular basis of plasticity, the evolution of synapses, and disease-related impairments of plasticity like the ones that cause Alzheimer's disease.
10/29/2015
10/22/2015
http://www.news.ucsb.edu/2015/015918/brain-trust
A Brain Trust An innovative neuroscience research program at UCSB crosses disciplinary lines
Studying the Outliers
https://www.nri.ucsb.edu/news/2015/studying-outliers
06/08/2015
Ken's take on tau over at The Dana Foundation's "Cerebrum" http://dana.org/Cerebrum/2015/Tau-er_of_Power/
Tau-er of Power Editor’s Note: Tau protein helps nerve cells in the brain maintain their function and structure. When tau turns toxic, replicates, and spreads, neurons misfire and die. If neuroscientists can pinpoint the reasons for toxicity, identify what our author calls “a staggering number of possible modified…
04/30/2015
What is & how does it differs from other forms of ? Listen to this podcast featuring Dr. Kosik: http://bit.nyas.org/1G7PsAF
Dementia Decoded: A Special Illness | The New York Academy of Sciences Polls show that Americans fear Alzheimer's disease more than any other illness. And little wonder - it's debilitating, fatal, incurable, and currently afflicts hundreds of millions worldwide, a number that's going to continue increasing as the world’s population both grows and grows older. But what…
02/18/2015
A wonderfully detailed three-part account of how Drs. Lopera and Kosik identified the early-onset Alzheimer's mutation and the progress of the clinical trial for a preventative drug. http://www.azcentral.com/longform/news/local/best-reads/2015/02/15/alzheimers-research-colombia-curse-part-one/23373503/
Solving the Alzheimer's mystery A region in Colombia has long been cursed with Alzheimer's. Now doctors there and in Arizona are using the group to test an experimental treatment.
10/27/2014
Dr. Kosik shares his thoughts on this study. http://www.nytimes.com/2014/10/27/us/a-bite-to-remember-chocolate-is-shown-to-aid-memory.html?emc=eta1&_r=0
A Bite to Remember? Chocolate Is Shown to Aid Memory A small study shows that an antioxidant in chocolate appears to improve some memory skills that people lose as they age.
10/20/2014
Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease - Alzheimer's &... To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect.
06/19/2014
http://www.news.ucsb.edu/2014/014239/cure-alzheimer%E2%80%99s-requires-parallel-effort
A Cure for Alzheimer’s Requires a Parallel Team Effort For people suffering from Alzheimer’s disease, the rate of progress in developing effective therapeutics has been unacceptably slow
05/27/2014
http://www.jhunewsletter.com/2014/03/27/scientists-track-primate-evolution-via-rnas-69710/
Scientists track primate evolution via RNAs | The Johns Hopkins News-Letter Rome wasn’t built in a day. Neither was the human brain. The intricate organ was crafted over millions of years before it developed into the functionally sophisticated masterpiece it is today. Just like the numerous workers who toiled in the hot Mediterranean sun to construct the roads, buildings an…
03/25/2014
Our most recent paper in Neuron https://labs.mcdb.ucsb.edu/kosik/kenneth/news/new-study-evolution-increased-primate-cortex-computational-abilities
New Study on the Evolution of Increased Primate Cortex Computational Abilities | Ken Kosik Lab |... Primate-specific miRNAs uniquely distinguish VZ and OSVZ compartments miRNAs distinguish internal and external subcompartments of the OSVZ in area 17 DE miRNAs target cell cycle, neurogenesis, and developmental disorder genes Emergent miRNAs coevolve with preexisting targets to integrate into gene c...
02/19/2014
Focus on Brain Disorders: Fogarty-supported researchers spur Alzheimer's research in Colombia Dr. Francisco Lopera was a resident in neurology when the first patient with dementia walked into the San Vicente de Paul hospital in Medellin, Colombia in 1984. "He was 47 years old and he had completely lost his memory over the past three or four years," Lopera recalled. "What was truly remarkable...
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