AMJ

Legionnaires’ disease: a hidden danger for people with cancer.

A study of 344 hospitalised adults found that cancer and immunosuppression were linked to more than twice the risk of death within 30 days. Standard urine tests also missed nearly three-quarters of confirmed cases.

The findings highlight the need for faster, more accurate diagnosis in vulnerable patients.

Read more: https://hubs.la/Q04y6j4K0

Could early HIV treatment help slow biological ageing?

Researchers found that untreated HIV was linked to almost six years of accelerated biological ageing, while suppressive antiretroviral therapy slowed this process.

The findings highlight the potential long-term benefits of starting treatment early.

Read more: https://hubs.la/Q04y6hQD0

Could a liver transplant affect lung health too?

A nationwide study found that liver transplant recipients had poorer lung function and more breathlessness than people without a transplant. Airflow limitation was also more than twice as likely after adjusting for key factors.

The findings highlight the importance monitoring lung health after liver transplantation.

Read more: https://hubs.ly/Q04y6fLv0

Could a closer look at the small airways help track asthma remission?

A study found that improvements in small airway function were linked to clinical remission in adults with severe asthma receiving biologic treatment.

The findings suggest small airway testing could offer another way to monitor treatment response — but more research is needed.

Read more: https://hubs.ly/Q04y6fw60

When multisystem symptoms don’t fit the usual picture, could MCTD be the missing diagnosis?

Three unusual cases reveal how mixed connective tissue disease can present with thrombocytopenia, pulmonary hypertension, or polyserositis that mimics other conditions.

Explore the cases:

The Many Faces of Anti-RNP Disease: A Case Series of Atypical Presentations of Mixed Connective Tissue Disease Mixed connective tissue disease (MCTD), first described by Gordon Sharp in 1972, is a systemic autoimmune overlap syndrome characterized...

Measles is back — and vulnerable patients could be at risk.

People with autoimmune rheumatic diseases may be more vulnerable to measles, particularly when taking treatments that suppress the immune system.

With around 95% vaccination coverage needed to maintain community protection, falling coverage could leave more immunosuppressed people exposed.

Read more: https://hubs.ly/Q04y6flC0

Molecular profiling could replace one-size-fits-all treatment in adrenal cancer.

A multi-omic analysis of 61 patients identified four distinct molecular subtypes, each with different prognostic and therapeutic implications.

The findings highlight potential targets for immunotherapy and CDK4/6 inhibitors, supporting a more personalised approach to treatment.

Read more: https://hubs.la/Q04xKvwh0

Could respiratory infections disrupt dormant cancer cells?

New research suggests influenza A and SARS-CoV-2 may trigger dormant breast cancer cells to resume growth in the lungs in mouse models.

The findings point to IL-6-driven inflammation as a possible mechanism, but human studies are needed to understand whether this could affect cancer recurrence.

Read more: https://hubs.la/Q04xKw3y0