Keck Lab

Keck Lab

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The Keck lab studies the basic mechanisms of DNA replication, recombination and repair.

Research in the Keck lab examines the structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions. Successful ex*****on of these pathways is essential in all cells, and defects in the proteins that facilitate genome maintenance reactions lead to genome instability, cell death, and disease. Our studies combine structural approaches with biochemical and cell biological methods to answer fundamental structure-function questions in genome biology.

12/04/2024

Check out this early holiday gift from our lab friend and collaborator, Kavi Mehta!

Three IPiB Grad Students Earn Awards for Exceptional Mentorship and Teaching 06/18/2024

Congratulations to Rachel Cueny who received the 2024 Sigrid Leirmo Memorial Award in Biochemistry!

Three IPiB Grad Students Earn Awards for Exceptional Mentorship and Teaching Christine Hustmyer (Landick Lab) and Max Rector (Record Lab) were awarded this year's Denton Award. Rachel Cueny (Keck Lab) was awarded this year's Leirmo Award.

05/30/2024

Congratulations to Dr. Rachel Cueny! She rocked our second defense in as many weeks! Excellent job!

05/17/2024

Congratulations to Dr. Sarah McMillan! A wonderful defense capping off an outstanding five years of scholarship in the lab!

05/10/2024

We’ve got a couple of (almost) graduates! Sarah defends in one week and Rachel defends in three!

IPiB Thesis Defense May 17, 2024: Sarah McMillan 05/01/2024

Get ready for Sarah's thesis defense on Friday May 17!

IPiB Thesis Defense May 17, 2024: Sarah McMillan McMillan’s research in the Keck Lab investigated replicative helicase and associated proteins.

AAAS members make six UW researchers new fellows 04/18/2024

As is always the case, this award is the lab’s award. Congratulations and thanks to all Keck Lab members past and present!

AAAS members make six UW researchers new fellows The honor, presented annually since 1874, recognizes efforts to advance science and society, with the fellows expected to maintain the highest standards of scientific integrity and professional ethics.

04/16/2024

Congratulations to Sarah McMillan whose paper describing how mutations of a helicase loader affect its biochemical function was just published in the Journal of Biological Chemistry!

12/17/2023

Ready for commencement to commence!

Identification of bacterial protease domains that cleave human IgM 12/15/2023

It is really neat to see two Keck lab alumni publishing together in their post-Wisconsin lives! Congratulations to Tricia Windgassen and Brian Ferrer!

Identification of bacterial protease domains that cleave human IgM Immunoglobulin-degrading proteases are secreted by pathogenic bacteria to weaken the host immune response, contributing to immune evasion mechanisms d…

12/14/2023

We are thrilled to welcome Molly Dolan and Zoe Wetmore, both graduate students in the Integrated Program in Biochemistry, to their PhD home in the Keck Lab!

11/20/2023

Oops! The American Society for Biochemistry and Molecular Biology will surely be getting some emails about this picture from its 2024 calendar!

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440 Henry Mall
Madison, WI
53706