Stem Cells Portal

Meet Dr. Salvatore Fusco – winner of the 2023 STEM CELLS Young Investigator Award. The Young Investigator Award is a prize granted annually to an early career scientist publishing a study with STEM CELLS that is deemed to be of global significance.

Mesenchymal stem cells (MSCs) had shown great therapeutic potential for tissue damage repair. Moreover, the use of MSCs in liver preservation also shown great therapeutic potential. In this review, we present current literature regarding different strategies for in vitro liver preservation and investigate the potential application of MSCs and derived EVs as an innovative therapeutic tool to precondition grafts before transplantation as well as to prevent ischemia-reperfusion injury.

Mesenchymal Stem Cell Utilization for In Vitro Donor Liver Machine Perfusion Preservation: Current Status and Future Directions Abstract. Liver transplantation is the only effective treatment for end-stage liver disease. Currently, the shortage of high-quality donors has led to the explo

NIH researchers work to preserve fertility for people undergoing gene therapy

NIH researchers work to preserve fertility for people undergoing gene therapy Researchers at NIH have created a novel gene therapy procedure that could preserve fertility in people with sickle cell disease and other genetic blood conditions.

A drug that boosts strength in injured or aging mice restores connections between nerves and muscle and suggests ways to combat weakness in humans due to aging, injury or disease.

Restoring nerve-muscle connections boosts strength of aging mice, Stanford Medicine study finds

The present study systematically summarizes the evidence on using all types of allogeneic cells relevant to the neonatal period in term and preterm infants from published and ongoing studies. The results show some evidence of the safety and feasibility of certain types of mesenchymal cells and highlight the lack of efficacy data for all the cell types. These findings suggest further research on a broader population of allogeneic cells is required, particularly emphasizing their efficacy related to the predominant morbidities that require therapeutic intervention in the neonatal period.

Allogeneic Cell Therapy Applications in Neonates: A Systematic Review AbstractBackground. Neonatal cell therapy applications are increasing; however, data on allogeneic cell therapy are limited.Objective. To summarize evidence on

MSCs exhibit therapeutic potential in MetS-related disorders. Gene editing, pretransplant pretreatment, and combination therapy have been applied to bolster the therapeutic potency of autologous or allogeneic MSCs.

Mesenchymal Stem/Stromal Cells Therapy for Metabolic Syndrome: Potential Clinical Application? Abstract. Mesenchymal stem/stromal cells (MSCs), a class of cells with proliferative, immunomodulatory, and reparative functions, have shown therapeutic potenti

Researchers have used heart and lung stem cells infected with SARS-CoV-2, the virus that causes COVID-19, to better understand how the disease impacts different organs. Responses varied significantly depending on the cell type, allowing the team to identify effective antiviral drugs to treat infection in these organs specifically, thus paving the way to more targeted treatment.

Stem Cells Show SARS-CoV-2's Different Effects In Heart and Lungs Researchers have used heart and lung stem cells infected with SARS-CoV-2 to find more targeted treatments for COVID-19. The virus, they find, has different effects in different cell types.

Congratulations to Dr. Jan Nolta for receiving the 2023 ISCT Career Achievement Award in Cell & Gene Therapy!
https://buff.ly/466O9X2

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.

Improving How Lab-Grown Mini Tumors Predict Cancer Therapy Responses Researchers develop new way to grow and measure how tumor organoids respond to therapy.

“The OMPULs will allow wider access to promising cell and gene therapies for patients in different regions of California, improving accessibility and reducing health care disparities.”

Bitly | Too Many Requests | 429 Error This is a 429 error. Try accessing this page directly or wait a few minutes and try again. Everyone has their limits, and we're getting too many requests right now.

CIRM invests $10 million to build California Cell and Gene Therapy Manufacturing Network
Posted: May 31, 2023

CIRM invests $10 million to build California Cell and Gene Therapy Manufacturing Network The California Institute for Regenerative Medicine (CIRM), the world’s largest institution dedicated to regenerative medicine, awarded $10 million to five facilities as part of the first phase to build a California Cell and Gene Therapy Manufacturing Network. The awards include: Application # Prog...

Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair Abstract. Severe trauma or chronic wounds can deplete the keratinocyte stem cells (KSCs) present in the epidermal basal layer or inhibit their migration leading