Simpson Querrey Institute

Chemical & Engineering News reported on recent research from SQI director Samuel Stupp's laboratory affirming that supramolecular motion is a key factor in biological signaling. The Stupp Lab has now seen this phenomenon in both neural tissue and cartilage cells.

Molecules move in the 4th dimension Supramolecular motion is key to biological activity

“Controlling supramolecular motion through chemical design appears to be a powerful tool to increase efficacy for a range of regenerative therapies.” — Prof. Samuel I. Stupp

‘Dancing Molecules’ Heal Cartilage Damage Professor Samuel Stupp found that regenerative effects of the molecules might be universal across tissue types.

New research from SQI director Samuel Stupp's laboratory describes an injectable 'nanoslurry' that regenerated high-quality, hyaline cartilage in the knee joints of large animals.

New biomaterial regrows damaged cartilage in joints Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model.

The National Institute of Biomedical Imaging and Bioengineering published a Science Highlight on new technologies to improve bladder surgery and monitoring, developed by SQI members Arun Sharma, Guillermo Ameer, and John Rogers. Their work is highly translational and combines regenerative medicine with bioelectronics.

Bladder buzz: technologies to improve bladder surgery and monitoring NIBIB-funded researchers are working to make bladder surgeries better, tackling the issue from two vantage points: improving bladder function using a biodegradable construct that facilitates tissue regeneration, and enhancing patient monitoring by developing an implantable bladder sensor.

New work in Science Advances from SQI member Guillermo Ameer describes a new antioxidant biomaterial that someday could provide much-needed relief to people living with chronic pancreatitis.

Antioxidant gel preserves islet function after pancreas removal Northwestern University researchers have developed a new antioxidant biomaterial that someday could provide much-needed relief to people living with chronic pancreatitis.

SQI member Evangelos Kiskinis appeared on a recent Northwestern University Feinberg School of Medicine
Breakthroughs Podcast to discuss his work to uncover novel cellular mechanisms involved in two types of genetic ALS. The findings may lead to future targeted therapies.

Discovering New ALS Therapeutic Avenues with Evangelos Kiskinis, PhD An estimated 32,000 Americans are currently living with ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Northwestern investigators have uncovered novel cellular mechanisms involved in two types of genetic ALS tha...

Jes Sanders is a fifth-year general surgery resident at Northwestern Memorial Hospital and a postdoctoral research fellow in the laboratory of SQI members James Mathew and Joseph Leventhal. In this interview, Sanders summarizes his main research project and explains why he was drawn to the field of transplant immunology.

Meet the Researchers: Jes Sanders: Simpson Querrey Institute (SQI) - Northwestern University In this interview, postdoctoral researcher Jes Sanders summarizes his Rising Stars of SQI Lecture and explains why he was drawn to the field of transplant immunology.

A team led by SQI members Guillermo Ameer, John Rogers and Arun Sharma has developed a new battery-free implant that allows users to monitor their bladder fullness in real time. The device could be a game-changer for people with paralysis, spina bifida, bladder cancer or end-stage bladder disease.

Gotta go? New bladder device lets you know New implantable sensor measures strain to detect bladder filling. Implant continuously streams data to smartphone, so users and their physicians can monitor filling/emptying in real time.

SQI members John Rogers and Arun Sharma have developed a wireless, implantable temperature sensor that can detect inflammatory flare-ups in Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.

Implantable sensor could lead to timelier Crohn’s treatment A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn’s disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the per...

A research team led by SQI member Arun Sharma has developed a synthetic, flexible “bladder patch” that outperformed the current standard surgery for severe bladder dysfunction in a long-term, large-animal model — the last step before beginning clinical trials.

Synthetic ‘bladder patch’ promotes tissue regeneration, restores function: Simpson Querrey Institute (SQI) - Northwestern University A research team led by SQI member Arun Sharma has developed a synthetic, flexible “bladder patch” that outperformed the current standard surgery for severe bladder dysfunction in a long-term, large-animal model — the last step before beginning clinical trials.

Northwestern University researchers led by SQI member Evan Scott have developed the first selective therapy to prevent allergic reactions, which can range in severity from itchy hives and watery eyes to trouble breathing and even death.

Decorated nanoparticles prevent allergic reactions Northwestern University researchers have developed the first selective therapy to prevent allergic reactions, which can range in severity from itchy hives and watery eyes to trouble breathing and even death.