LifeCanvas Technologies

New in the of stress: Melanie Schaffler et al. demonstrate a key role for touch neurons in a skin-brain pathway that modulates stress vulnerability, leveraging LifeCanvas' whole brain c-FOS mapping services.

A critical role for touch neurons in a skin-brain pathway for stress resilience Social touch can act as a stress buffer, reducing behavioral and physiological responses to stressful scenarios. However, skin-brain touch pathways that promote stress resilience remain unknown. Here, we show that mice with an early life genetic ablation of Mrgprb4-lineage touch neurons display stre...

Mapping expression of the immediate early gene c-FOS can help scientists track responses to a variety of stimuli. In our new blog, Dr. Brian Nguyen discusses key considerations for studying c-FOS in projects, including the power of 3D , , and analysis tools.

c-FOS Brain Mapping: Challenges & Solutions Our whole brain mapping services take the guesswork out of systematically studying changes in c-FOS expression.

To simplify the demo process, we have introduced the SmartBatch+ curriculum: a guided protocol for your first experiment. Visit the SmartBatch+ page to learn more and demo our tissue clearing and labeling platform today!
https://lifecanvastech.com/products/smartbatch/

Dr. Adam Hall will join Dr. Moriah Jacobson from Taconic Biosciences in discussing innovative applications of our intact tissue processing and light sheet to , using Taconic's robust mouse models. Register at https://bit.ly/3w15Ozo to learn more about innovations in neurodegeneration research!

Our Head of Scientific Affairs, Dr. Adam Hall, met up with Marine Biological Laboratory investigator Dr. Abhishek Kumar to discuss applications of light sheet !

Using LifeCanvas tools, Dheeraj Roy et al. provide compelling evidence that a single memory is stored across multiple brain regions in mammals – a profound discovery in .

Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions - Nature Communications Where memories are located in our brains is not well understood. In this paper, the authors demonstrate that memories are spread out throughout multiple brain regions.

Congratulations to Nudell et al. in Li Ye's lab at Scripps Research on their publication of a new method! Check out the paper in Nature Methods to see how the team used and other LifeCanvas tools to develop their technique, including impressive images of whole-mouse clearing. To learn more about Dr. Ye's , take a look at his recent Portrait on our website.

HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodies - Nature Methods HYBRiD is a tissue-clearing approach that combines elements of solvent-based and aqueous, hydrogel-based methods, thereby achieving high transparency while maintaining fluorescence.

Ghosh et al. recently used , SHIELD, fMRI & a novel genetic probe to explore the functional roles of neural populations in interconnected regions of the rat brain. Check out their paper in Nature !

Functional dissection of neural circuitry using a genetic reporter for fMRI - Nature Neuroscience This study introduces genetically encoded imaging probes that convert intracellular calcium signaling into hemodynamic fMRI responses. The authors show how the probes can be used to map information flow in reward-related brain circuitry in rats.

How does 3D compare to IHC for neurological disorder research? Read our new blog to see how our partnership with Taconic Biosciences reveals groundbreaking spatial information in their robust mouse models, with far-reaching implications for , , & !

Pictured: Microglia (magenta) cluster around β-amyloid plaques (cyan) in brain of ARTE10 (disease model # 16347) mouse from Taconic Biosciences. Imaged at 15X with .

IHC vs. 3D histology: The future of neurological disorder research - LifeCanvas Technologies Neuroscientists studying major neurological disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases frequently use transgenic mouse models to evaluate disease progression and the impact of potential therapies. For instance, mice with overexpression of Alzheimer’s related protei...

Loading and actively clearing up to 12 whole mouse-brain-sized samples is easy with SmartBatch+! https://youtu.be/BOQoP-mWQP4

Easy Sample Loading and Tissue Clearing with SmartBatch+ Visit lifecanvastech.com/products/smartbatch for our full SmartBatch+ active tissue processing protocol.

Just how easy is our SmartBatch+ tissue processing workflow? Take a look for yourself! Learn more on our website: https://lifecanvastech.com/products/smartbatch/

G. Allan Johnson of Duke University & collaborators have published a new study combining magnetic resonance histology with SmartSPIM light sheet & other LifeCanvas tools to accurately map mouse brains in 3D!

HiDiver: A Suite of Methods to Merge Magnetic Resonance Histology, Light Sheet Microscopy, and Complete Brain Delineations We have developed new imaging and computational workflows to produce accurately aligned multimodal 3D images of the mouse brain that exploit high resolution magnetic resonance histology (MRH) and light sheet microscopy (LSM) with fully rendered 3D reference delineations of brain structures. The suit...