Dr Muqaddar Rph Official

Solifen
Therapeutic Segment:
Overactive Bladder

Generic Name:
Solifenacin Succinate

Mechanism of Action:
Solifenacin is a competitive, specific cholinergic-receptor
antagonist.The urinary bladder is innervated by
parasympathetic cholinergic nerves.Acetylcholine contracts
the detrusor smooth muscle through muscarinic receptors
of which the M3 subtype is predominantly involved.
Solifenacin is a competitive inhibitor of the muscarinic M3
subtype receptor

THERAPEUTIC INDICATIONS:
SOLIFEN (Solifenacin Succinate) is indicated for the
symptomatic treatment of urge incontinence and/or
increased urinary frequency and urgency as may occur
in patients with overactive bladder syndrome.

ADVERSE REACTIONS
Very common
Dry mouth.
Common
Constipation, nausea, dyspepsia, abdominal pain, blurred
vision.
Uncommon
Gastroesophageal reflux diseases, dry throat, urinary
tract infection, cystitis, somnolence, dysgeusia, dry eyes,
fatigue, peripheral edema, nasal dryness, dry skin, difficulty
in micturation.
Rare
Colonic obstruction, f***l impaction, urinary retention.

CONTRAINDICATIONS
Solifenacin Succinate is contraindicated in patients with:
- Hypersensitivity to the active substance or to any of the
excipients.
- Urinary retention.
- Gastric retention.
- Uncontrolled narrow-angle glaucoma.
- Patients undergoing hemodialysis.
- Patients with severe hepatic insufficiency and renal
insufficiency.

DOSAGE & ADMINISTRATION
SOLIFEN (Solifenacin Succinate) should be taken with
liquids and swallowed whole. SOLIFEN (Solifenacin
Succinate) can be administered with or without food.
Adults
The recommended dose of SOLIFEN (Solifenacin
Succinate) is 5mg once daily. If needed, the dose may
be increased to 10mg once daily.
Patients with renal insufficiency
Patients with severe renal insufficiency (Clcr