UIRRG

Together with my colleagues from Vienna and Nice we published a review on the development of inward rectifier current activators

BPS Publications Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non-excitable tissues. Although KIR channels exhibit a biophysical preference for potassiu...

Just published. Our latest paper on the development of Kir2.1 activators.

BPS Publications Background and Purposes Reduced inward rectifier potassium channel (Kir2.1) functioning is associated with heart failure and may cause Andersen-Tawil Syndrome, among others characterized by ventricu...

We published a review on developments in Kir2.1 pharmacological tools

The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues - Naunyn-Schmiedeberg's Archives of Pharmacology The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity. One of the key players contributing to this intricate system is the KIR2.1 potassium ion channel, which is encoded by the KCNJ2 gene. KIR2.1 channel...

Our latest paper on the influence of chronic propafenon application on Kir2.1 expressing cells

Chronic Propafenone Application Increases Functional KIR2.1 Expression In Vitro Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but contributing to the final stage of repolarization and....

Our latest paper on Kir2.1 ion channel trafficking, and its dependence on the cytoskeleton, has just been published in Frontiers in Physiology.

Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel trafficking. Cellular....

We just published our latest work on the development of IKATP inhibitors. A good collaboration with our friends in Vienna.

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channel, stand at the basis of most forms of DEND syndro...

Our latest review on the CAVB dog and its place in pharmacological research for over the last 100 years is now published open access.

BPS Publications Ventricular cardiac arrhythmia is a life threating condition arising from abnormal functioning of many factors in concert. Animal models mirroring human electrophysiology are essential to predict and...

Our group member Muge defended her excellent thesis yesterday. We are very proud on the performance of Dr. Qile!

We just published our work on the development of new Kir2 channel agonists, that we call AgoKirs.

https://www.mdpi.com/1422-0067/21/16/5746/htm

Our work is on the cover page of Molecular Pharmacology