UIRRG

Together with my colleagues from Vienna and Nice we published a review on the development of inward rectifier current activators

BPS Publications Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non-excitable tissues. Although KIR channels exhibit a biophysical preference for potassiu...

Just published. Our latest paper on the development of Kir2.1 activators.

BPS Publications Background and Purposes Reduced inward rectifier potassium channel (Kir2.1) functioning is associated with heart failure and may cause Andersen-Tawil Syndrome, among others characterized by ventricu...

We published a review on developments in Kir2.1 pharmacological tools

The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues - Naunyn-Schmiedeberg's Archives of Pharmacology The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity. One of the key players contributing to this intricate system is the KIR2.1 potassium ion channel, which is encoded by the KCNJ2 gene. KIR2.1 channel...

Our latest paper on the influence of chronic propafenon application on Kir2.1 expressing cells

Chronic Propafenone Application Increases Functional KIR2.1 Expression In Vitro Expression and activity of inwardly rectifying potassium (KIR) channels within the heart are strictly regulated. KIR channels have an important role in shaping cardiac action potentials, having a limited conductance at depolarized potentials but contributing to the final stage of repolarization and....