Microflash

The study indicates that the three BA.2 sublineages are causing mild disease in India. However, BA.2.75 has key mutations that are notable for accelerated growth and transmission and require close and effective monitoring.

An Early and Preliminary Assessment of the Clinical Severity of the Emerging SARS-CoV-2 Omicron Variants in Maharashtra, India Background: The SARS-CoV-2 Omicron variants BA.2.74, BA.2.75, and BA.2.76 have appeared recently in India and have already spread to over 40 countries. They have acquired additional mutations in their spike protein compared to BA.2, branching away on the SARS-CoV-2 phylogenetic tree. These added mut...

Microbiome - Friends forever! Department of Microbiology,  Byramjee Jeejeebhoy Government Medical College and Sassoon Hospitals, Pune-411001, Maharashtra, India

Does EBV Cause MS?Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.

The Department of Microbiology, B J Government Medical College and Sassoon General Hospitals, Pune, is hosting, “MAHAMICROCON-2020”, the XXVI Maharashtra Chapter Conference of Indian Association of Medical Microbiologists on 12th and 13th September, 2020, with a pre-conference CME. Kindly visit http://www.xxvimahamicrocon2020.in for detail.
Kindly associate with us for this academic feast.
Dr Rajesh Karyakarte
Organizing Secretary,
Deputy Dean, BJGMC, Pune.

XXVI Maharashtra Chapter Conference of IAMM

US FDA approves first siderophore antibiotic, Fetroja - ID Hub The FDA has approved Fetroja, a siderophore cephalosporin that inhibits bacterial cell wall synthesis and binds free iron to gain additional cell entry,

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Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease In patients with alcoholic hepatitis, cytolysin-positive Enterococcus faecalis strains are correlated with liver disease severity and increased mortality, and in mouse models these strains can be specifically targeted by bacteriophages.

Issue no. 5, November 2019.

November issue displayed on notice board, Microbiology department, BJGMC, PUNE.
Microbiome...

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A gain in the neck Unique conditions in a tapeworm’s neck enable stem cells to rapidly grow new body segments.

New antimicrobial... New hope......."This series of compounds were named “nusbiarylins” based on their target protein NusB and the biaryl structure and were expected to be further developed towards novel antimicrobial drug candidates in the near future.".....

Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins Discovery of antibiotics of a novel mode of action is highly required in the fierce battlefield with multi-drug resistant bacterial infections. Previo…

New issue!

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