Cyclolab Kft

The CycloLab’ Szejtli award committee, has decided to award the 2022 , to Dr. Angela Scala, Associate Professor of Organic Chemistry at the University of Messina for her outstanding contribution the synthesis, characterisation and application of amphiphilic . The award was presented by Dr. Lajos Szente.

On behalf of Cyclolab Kft, we all congratulate Angela Scala on her great achievements and wish her continued success in her future scientific career.🏆👏

The CycloLab’ Szejtli award committee, has decided to award the 2020 , to Dr. Aurore Fraix for her outstanding contribution to the -related works and results. As the conference was not held in 2020, the prize was handed to the awardee in 2022, by Dr. Lajos Szente.

On behalf of Cyclolab Kft, we congratulate Aurore Fraix on her remarkable scientific carreer and achievements and wish her continued success in her future works.👏🏆

participated at the 20th International Symposium with 6 researchers.
According to the abstract book, CycloLab researchers were among the authors of altogether 25 presentations: keynote (1), oral (10) flash (3) and poster (11) in collaboration with various academic research institutes, universities and companies.
Continuing the traditions, Szejtli prize was awarded to young for their outstanding contribution to the cyclodextrin research. The main objective of the prize given in every second year during the International Cyclodextrin Symposia to preserve the memory of Prof. József , the big cyclodextrin chemist who initiated the industrial production and applications and left a remarkable footprint in the development of cyclodextrins. This time two awardees were celebrated: Aurore Fraix (Catania University, laboratory of Prof. Salvatore Sortino) received the 2020 Szejtli prize and Angela Scala (University of Messina, laboratory of Prof. Antonino Mazzaglia) obtained the 2022 Szejtli prize. The awardees showed high activity in the research of cyclodextrin-based photoactivatable drug delivery systems and of amphiphilic cyclodextrin derivatives and nanoparticles, respectively. Prof. Lajos Szente, successor of Prof. József Szejtli in CycloLab gave an unscheduled talk on the life and achievements of Prof. József Szejtli (1933–2004) for those who could not meet this internationally recognized scientist, the “Godfather of Cyclodextrins”, personally.

The expected so long was concluded on 17 June, Friday. The about 160 participants (the detailed statistics come soon) agreed on the importance of the personal meetings and discussions. The symposium gave this opportunity.

The 3 plenary presentations by highly recognized Prof. Stodart, Prof. Ito and Prof. Sollogoub gave an insight into the CD-based MOFs, the sliding gels (already used in the car industry) and synthesis of derivatives as artificial proteins, respectively.

In addition to the 16 keynote and 44 oral presentations including also the talks of the two awardees: Aurore Fraix (Catania University) and Angela Scala (University of Messina) 62 posters were displayed in the widest range of CD applications. During the fruitful discussions in the auditorium, during poster sessions and coffee breaks we could share ideas and start new collaborations.

The conference started with an excursion to the Mount Etna one day after a smaller eruption at sunset. During the gala dinner we enjoyed the excellent Italian food and the beautiful panorama to Taormina Bay.

Thanks are due to the organizers, especially to Prof. Mazzaglia and his team for organizing such an interesting scientific event and unique social programs on a so beautiful place in Sicily.

-summary by Dr. Éva Fenyvesi

It has been an amazing week at the 20th International Conference .

Thanks to our Colleagues for representing us with a great balance of passionate Senior Scientists with 50+ years of experience in the field of CDs and enthusiastic and young Researchers full of great ideas.

Such inspiring listening to the importantance of József Szejtli and his significant work has been done in the field of .

Congratulations to Aurore Fraix and Angela Scala for their , presented by Lajos Szente

Many thanks for the amazing talk being delivered yesterday by our Senior Scientific Advisor, Dr. Éva Fenyvesi on the topic of Cyclodextrin-enabled green environmental technologies.

Cyclolab Kft is proud to be a sponsor of the 20th International Cyclodextrin Symposium in Sicily, Italy.

🎌Alpha-CD powder and tablets in Japan🎌

😎 Consumption of pure or flavoured a-CD is becoming a trendy, fashionable custom in Japan. Various products are available in both tablet and powdered form. The packaging is prestigeous, eyecatching, elegant or cute.

❕ These products not only promise to improve the digestion by swallowing this undigestable fiber but also body weight loss via fat binding.

📢CYCLOLAB IS ON TWITTER📢
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❗️❗️STOP SCROLLING❗️❗️
Check this intriguing interview with Dr. István Puskás, where he explains how Cyclolab was challenged to prepare an aqueous solution of a surfactant type of API.🤔

https://drug-dev.com/special-feature-outsourcing-formulation-development-manufacturing-understanding-critical-attributes-earlier-in-development-leads-to-a-more-robust-drug-product/

SPECIAL FEATURE - Outsourcing Formulation Development & Manufacturing: Understanding Critical Attributes Earlier in Development Leads to a More Robust Drug Product Contributor Cindy H. Dubin speaks with industry leaders on how drug sponsors and CDMOs are collaborating earlier, and highlights how third-party contractors are navigating material shortages and how the industry is shifting to address different therapeutic targets and molecules, such as mRNA.

pH-Responsive templates modulate the dynamic enzymatic synthesis of cyclodextrins🍩

Product selection in the dynamic enzymatic synthesis of can be controlled by changing the pH. Using cyclodextrin glucanotransferase to make labile the glycosidic linkages in cyclodextrins (CDs), a dynamic combinatorial library of interconverting linear and cyclic α-1,4-glucans was generated.

Templates can be employed to favour the selective production of specific CDs and, herein, we show that by using ionisable templates, the synthesis of α-CD or β-CD can be favoured by simply changing the pH. Using 4-nitrophenol as the template, β-CD is the preferred product at low pH, while α-CD is the preferred product at high pH.

❗️Furthermore, a new methodology is described for the simulation of product distributions in dynamic combinatorial libraries with ionisable templates at any given pH.

Lisa Samuelsen, Dennis Larsen, Christian Schönbeck and Sophie R. Beeren (2022) pH-Responsive templates modulate the dynamic enzymatic synthesis of cyclodextrins. Chem. Commun., 58, 5152-5155