Neuronet

Have a read of the latest Innovative Health Initiative (IHI) funded publication investigating the association between different AD polygenic risk scores (PRS) and amyloid accumulation in the Flemish Prevent AD Cohort KU Leuven (F-PACK).

Congratulations to the authors Emma Luckett, Yasmina A., Mariska Reinartz, Kasia Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen & Rik Vandenberghe!

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults - Alzheimer's Research & Therapy Background Early detection of individuals at risk for Alzheimer’s disease (AD) is highly important. Amyloid accumulation is an early pathological AD event, but the genetic association with known AD risk variants beyond the APOE4 effect is largely unknown. We investigated the association between di...

Have a read of the latest Innovative Health Initiative (IHI) funded study, investigating the performance of participants with and without diabetes on a task of allocentric spatial processing.

Congratulations to the authors Sarah Gregory, Kaj Blennow, Natalie Homer, Craig Ritchie, Graciela Muniz Terrera and the whole consortium!

Self‐reported diabetes is associated with allocentric spatial processing in the European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study Type 2 diabetes is a robust predictor of cognitive impairment. Impairment in allocentric processing may help identify those at increased risk for Alzheimer’s disease dementia. The objective of this s...

📢 Mobilise-D Webinar: Multiple Sclerosis 📢

Just one week until our first webinar this autumn!

📅 Wednesday, September 7
⌚️ 16:00 CET
🆓 Free and open to the public

Haven't signed up yet? Register now👇

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

Read the latest Innovative Health Initiative (IHI) funded publication that found a significant interaction between APOE status, s*x, and CSF Aβ on CSF p-tau levels

Congratulations Tyler Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchie and Graciela Muniz Terrera!

Interactions between apolipoprotein E, s*x, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS) An interaction between s*x and cerebrospinal fluid Aβ may mediate the relationship between APOE status and CSF p-tau. These data suggest tau accumulation may be independent of Aβ in females, but not males.

The goal of the Innovative Health Initiative (IHI) funded PRISM 2 project is to build on the achievements of the original PRISM project. Specifically, it aims to validate PRISM’s findings on social dysfunction in schizophrenia and Alzheimer’s disease, and investigate whether they also apply to major depressive disorder.

https://vimeo.com/687937223

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Cindy Birck from Alzheimer Europe who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration

Spotlight on Communication experts: A Neuronet Blog with Cindy Birck Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

Have a read of the latest Innovative Health Initiative (IHI) funded publication outlining the current knowledge around the vital role of the apoptosis-inducing factor by primarily focusing on currently reported human diseases that have been linked to AIFM1 deficiency.

Congratulations to the authors Lena Wischhof, Enzo Scifo, Dan Ehninger, Daniele Bano and the whole consortium!

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00413-3/fulltext

📢Four NEW Mobilise-D webinars this autumn📢

We will show you the project cohorts and the status of the clinical trials. In the first webinar we present our cohort.

Save the dates(s) and register now⤵️

📅 September 7th
⌚️16:00 CET

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

The Biomedical Knowledge Miner (BiK>Mi) has been developed as part of the Innovative Health Initiative (IHI) funded project at Fraunhofer SCAI.
This platform provides tools to access & validate knowledge pertaining to 's disease.

Find out more:

The Biomedical Knowledge Miner (BiK>Mi) A tool to access & validate knowledge pertaining to Alzheimer's disease. Check it out now.

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Yoanna de Geus from Lygature who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration 🧠 RADAR-CNS & RADAR-AD ⤵️

Spotlight on Communication experts: A Neuronet Blog with Yoanna de Geus Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

The Alzheimer’s Association International Conference is the largest and most influential international meeting dedicated to advancing dementia science. Each year, AAIC convenes the world’s leading basic science and clinical researchers, next-generation investigators, clinicians and the care research community to share research discoveries that’ll lead to methods of prevention and treatment and improvements in the diagnosis of Alzheimer’s disease. This year, the conference took place from 31st July to 4th August as a hybrid event (online and in San Diego, US) and attracted over 10,000 attendees.

We were pleased that several EPAD researchers presented their respective work at the Alzheimer’s Association International Conference

– Sarah Gregory (UEDIN): “Does adherence to the Mediterranean diet have differential effects on brain health for those living within and outside of the Mediterranean region?”

– Luigi Lorenzini (VUmc): “Concerted alterations of functional connectivity and WM integrity in relationship to early amyloid deposition”

– Luigi Lorenzini (VUmc): “Functional eigenvector centrality dynamics are related to amyloid deposition in preclinical Alzheimer’s Disease.”

– Gonzalo Sánchez Benavides (BBRC) “Re-examining the impact of adjusting for education and s*x the RBANS delayed memory score: Implications on the cut-offs used to detect cognitive impairment in prodromal Alzheimer’s disease. Data from the EPAD-LCS study.”

– Irene Cumplido Mayoral (BBRC) “Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration.

https://www.imi-neuronet.org/epad-presented-at-aaic2022/

Our Innovative Health Initiative (IHI) funded IMI2_Neuronet Decision Tool provides a clickable overview of the processes and procedures for Health Technology Assessment & regulatory interactions at different stages of the development pipeline

https://kb.imi-neuronet.org/admin/decision_tool