Immuno ICS

A link we have been long looking for...

Dysregulated miR-155 and miR-125b Are Related to Impaired B-cell Responses in Down Syndrome Children with Down Syndrome (DS) suffer from immune deficiency with a severe reduction in switched memory B cells and poor response to vaccination. Chromosome 21 encodes two microRNAs (miRs), miR-125b and miR-155, that regulate B-cell responses. We investigated the expression of miR-125b and miR-155...

JCI Insight - Antigen-mediated regulation in monoclonal gammopathies and myeloma Address correspondence to: Madhav V. Dhodapkar, HSRB E330 Emory University, 1760 Haygood Drive, Atlanta, Georgia 30322, USA. Phone:404.727.8372; Email: [email protected].

Interesting paper:
http://jem.rupress.org/content/early/2019/03/26/jem.20181430

Page Not Found | JEM

http://jem.rupress.org/content/early/2019/03/26/jem.20181430r

Interesting

Aire-expressing ILC3-like cells in the lymph node display potent APC features The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here...

Aire-expressing ILC3-like cells in the lymph node display potent APC features The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here...

New and intersting story that may explain the role of AIRE in peripheral tolerance

Aire-expressing ILC3-like cells in the lymph node display potent APC features The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here...

Something really great is happening in gene therapy, already correcting the germinal line,
When could be applied to somatic cells?

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html
A dream coming true?

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html

Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research Nature | Article Print Share/bookmark Cite U Like Facebook Twitter Delicious Digg Google+ LinkedIn Reddit StumbleUpon Previous article Nature | News and Views Biotechnology: At the heart of gene edits in human embryos Next article Nature | Article Integrative clinical genomics of metastatic cancer C...

Fantastic advices!!! not always easy to follow
http://dx.plos.org/10.1371/journal.pcbi.0030213

Ten Simple Rules for Doing Your Best Research, According to Hamming Erren TC, Cullen P, Erren M, Bourne PE (2007) Ten Simple Rules for Doing Your Best Research, According to Hamming. PLoS Comput Biol 3(10): e213. https://doi.org/10.1371/journal.pcbi.0030213

Worth reading; In Spanish we have a name for them "fantasmas"
ttp://genomebiology.com/2014/15/7/424

The Kardashian index: a measure of discrepant social media profile for scientists In the era of social media there are now many different ways that a scientist can build their public profile; the publication of high-quality scientific papers being just one. While social media is a valuable tool for outreach and the sharing of ideas, there is a danger that this form of communicati...

A new neurological autoimmune disease

Autoimmunity in nodding syndrome

Nature 542, 395 (23 February 2017) doi:10.1038/542395d

In Tanzania, Uganda and South Sudan, nodding syndrome causes children's heads to drop and results in epileptic seizures, cognitive impairment and sometimes death. Although people with the syndrome are often infected with the parasitic worm Onchocerca volvulus (pictured), researchers have not found a causal link between the two.

Now, a team led by Avindra Nath at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, has discovered that people with nodding syndrome have higher levels of antibodies against a protein called leiomodin-1 than do healthy people from the same village. The researchers show that leiomodin-1 is made by human neurons and by key parts of the mouse brain. This protein is structurally similar to those made by O. volvulus, and antibodies that react against O. volvulus do the same against leiomodin-1, suggesting an autoimmune response.

People with the syndrome currently receive anti-epilepsy drugs, but the findings suggest that they might also benefit from therapies that modulate the immune system, the authors say.

Sci. Transl. Med. 9, eaaf6953 (2017)