BerningerLab

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Glad to report some success in our quest for inducing glial cells to turn into neurons with specific properties. Now you can read it here!

Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site–deficient Ascl1 Mouse cortical glia can be converted into neurons featuring hallmarks of an important subclass of cortical interneurons.

Before my much belated inaugural lecture "The Art of Forging Neurons" at the Institute of Psychiatry, Psychology and Neuroscience with our dean Professor Matthew Hotopf and the director of the Centre of Developmental Neurobiology Professor Oscar Marin. What a great evening it was!

Congrats to Nicolas Marichal for an EMERGING LEADER FELLOWSHIP AWARD of the EPILEPSY RESEARCH INSTITUTE UK

Research Awards 2024

https://roymaimonel.wixsite.com/cajalschalange

Home | Cajal’s challenge accepted: Sharpening the tool box for in vivo cell fate conversion Cajal’s challenge accepted (second edition): "Overcoming the barriers in making new neurons in the adult brain: lessons from nature”

I look forward to speaking on EMERGING NEW THERAPIES at taking place in Hamburg, Germany on 10-13 July 2024! Join me and register today. Learn more: https://www.isscr2024.org

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Concurrent Sessions — ISSCR 2024 Concurrent sessions feature scientists from around the world sharing their latest research in smaller, focused presentations. See who is speaking during ISSCR 2024.

https://kclmentalhealthphd.co.uk/apply

Funding, Eligibility & How to Apply — PhD Programme in Mental Health Research for Health Professionals Funding, Eligibility & How to Apply   Applications for October 2024 entry are now closed. Please see the ‘How to Apply’ section below to learn about the recruitment process.   Funding Funded by Wellcome and King’s College London. Each fellow receives the following funding:Three years salary ...

Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2

Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2 Adult neural stem cells in the ventral subependymal zone (SEZ) generate mainly GABAergic neurons. In this work, Berninger, Gascón, and colleagues show that the proneural factor Neurog2 can program ventral SEZ progenitors toward a glutamatergic fate but fails to reprogram their progeny once they ent...

https://www.kcl.ac.uk/dentistry/research/multiscale-models-for-life-mm4l-centre-for-doctoral-training

Multiscale Models for Life (MM4L) Centre for Doctoral Training | Faculty of Dentistry, Oral & Craniofacial Sciences | King’s College London Training future research leaders adept at bridging the gap between in vivo life sciences and multi-scale modelling

New preprint from our lab: Reprogramming early cortical astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site deficient Ascl1 https://www.biorxiv.org/content/10.1101/2023.11.03.565289v1

New preprint from our lab: Reprogramming early cortical astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site deficient Ascl1

Reprogramming early cortical astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site deficient Ascl1 Cellular reprogramming of mammalian glia to an induced neuronal fate holds potential for restoring diseased brain circuits. While the proneural factor Ascl1 is widely used for neuronal reprogramming, in the early postnatal mouse cortex Ascl1 fails to induce glia-to-neuron conversion, instead promoti...