Fischerlab

https://uni-koeln.de/en/university/news/news/news-detail/possible-therapeutic-approach-to-treat-diabetic-nerve-damage-discovered

Possible therapeutic approach to treat diabetic nerve damage discovered Researchers have decoded the signalling pathway that inhibits nerve regeneration in diabetes and have developed a therapeutic peptide that could transform the treatment—and possibly even the prevention—of diabetic nerve damage.

Failure of nerve regeneration in mouse models of diabetes is caused by p35-mediated CDK5 hyperactivity Mouse and cell models suggest that GSK3β and the p35-CDK5-CRMP2 axis are potential therapeutic targets for promoting nerve repair in diabetes.