Robert Vacha Lab

Burst or bust? What enables genome release from viral capsid? Watch this mesmerizing video.
You can learn more in https://pubs.acs.org/doi/10.1021/acsnano.1c04814

Genome release from virus capsid via large openning What enables RNA release from non-enveloped viral capsid? https://doi.org/10.1021/acsnano.1c04814

There are PhD and postdoc positions funded by ERC available in our lab. More info at https://vacha.ceitec.cz/jobs-openings/

Our member Lukáš Sukeník got his research published in ACS Nano. Congratulations!

Cargo Release from Nonenveloped Viruses and Virus-like Nanoparticles: Capsid Rupture or Pore Formation Virus-like nanoparticles are protein shells similar to wild-type viruses, and both aim to deliver their content into a cell. Unfortunately, the release mechanism of their cargo/genome remains elusive. Pores on the symmetry axes were proposed to enable the slow release of the viral genome. In contras...

Robert explained our work for Český rozhlas.

Odolnost bakterií vůči antibiotikům už nemusí být problém. Novou zbraň vyvíjí brněnští vědci Bakterie si vždycky vytvořily odolnost vůči lékům, které lékaři a biochemici proti nim objevili. Těm už v poslední době začaly docházet nápady, čím ještě by se daly bakterie potlačovat. O průlom se teď pokusí brněnští vědci, kteří zahajují výzkum peptidů. Zdá se, ž...

We have a brand new article out.

Selecting Collective Variables and Free-Energy Methods for Peptide Translocation across Membranes The selective permeability of cellular membranes is a crucial property for controlled transport into and out of cells. Molecules that can bypass the cellular machinery and spontaneously translocate across membranes could be used as therapeutics or drug carriers. Peptides are a prominent class of suc...

We can proudly announce that our group is a new ERC Consolidator Grant holder!
We will receive a €2.3 million research grant from the European Research Council for our research.
Read more here:

Robert Vacha from CEITEC Received the ERC Consolidator Grant to Fight Antibiotic Resistance on the Molecular Level Press Release Today, the European Research Council (ERC) announced the winners of its latest Consolidator Grant competition, which includes 327 top scientists and scholars from 23 countries across Europe. Funding for these researchers, as part of the…

ATTENTION! ATTENTION!

We have opened a new position for a postdoc to work on antimicrobial peptides.

Details here in the link:

http://vacha.ceitec.cz/news/hiring-postdoc/?fbclid=IwAR3vY0R3U3mXASI7iKGkx0p3TJ4Wfk_DvKrIVT1aW3-E61FqI74BtD204sI

GREAT SUCCESS!
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We were awarded ERC CZ grant to study antimicrobial peptides!
It is one of the largest direct scientific grants funded by Czech government.You can find more details in CEITEC press release.

Two Scientists from CEITEC Masaryk University Received ERC-CZ Grants. They Will Focus on Infections Two CEITEC MU projects received over 110 million CZK for research on bacterial and viral infections. Robert Vacha and Gabriel Demo both applied for the ERC CZ grant, and their research proposals were evaluated as the top two research projects from the eight supported projects in the Czech…

Dear physicists :)

💻 Let me introduce a colleague 🔬
MICHAEL OWEN
from Robert Vacha Lab!

RESEARCH I According to research by Canadian scientist Michael Owen from C E I T E C Masaryk University, what we eat can have an effect, especially in relation to Alzheimer´s disease.

Michael is involved in computational chemistry, in which he is studying the structure of proteins in detail and looking for factors that lead to Alzheimer's disease in humans.

“We study lipids that one can obtain from food. However, it is certainly not that straightforward. It all depends on how our body processes food and regulates its activity. There are still a number of unknown factors that affect the food we eat and how our diet in turn affects the structure of a particular protein in the brain,” he says.

Michael has lived in Europe for many years, and in his free time, he enjoys cycling and exploring the beauty of South Moravia.
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VÝZKUM I Podle výzkumu kanadského vědce Michaela Owena z C E I T E C Masarykova univerzita může mít to, co jíme, vliv na Alzheimerovu chorobu.

Michael se věnuje výpočetní chemii, díky které může detailně studovat strukturu bílkovin a hledat faktory, které přispívají k tomu, že propukne Alzheimerova choroba.

„Studujeme lipidy, které může člověk získávat z potravy. Ale určitě to není nijak jednoduchá cesta. Vše závisí na tom, jak naše tělo zpracovává potravu a jak reguluje svou činnost. Mezi tím, co sníme a jak to může ovlivnit strukturu konkrétního proteinu v mozku, je celá řada neznámých faktorů," říká.

Michael žije v Evropě mnoho let a ve svém volném čase se věnuje cyklistice a objevování krás jižní Moravy.

What We Eat Can Have an Effect, Even on Alzheimer´s Disease Michael Owen comes from Toronto, Canada, but has lived in Europe for about eight years. He spent the last two and a half years in Brno, more specifically at CEITEC Masaryk University, where he is engaged in research of Alzheimer's disease. He is investigating why the essentially harmless amyloid…

Well...