Viruses MDPI

📢 Call for Papers: Oncogenic Viruses in Animals and Zoonotic Risks

Oncogenic viruses cause significant disease in livestock, companion animals, and wildlife – but some can also cross species barriers, raising concerns within the One Health framework.

This Special Issue of Viruses welcomes original research and reviews on:
-Mechanisms of viral oncogenesis
-Cross-species infection and host-switch events
-Zoonotic transmission of animal viruses
-Potential links between animal viruses and human cancers

Retroviruses such as bovine leukemia virus (BLV) and mouse mammary tumor virus (MMTV) – with their hypothetical association with human breast cancer – are of particular interest, as are papillomaviruses and polyomaviruses.

📅 Submission deadline: 31 March 2027

👉 Learn more and submit:
https://www.mdpi.com/journal/viruses/special_issues/3FY2O6BZ5Y

🥰Guest Editors: Dr. Guillermina Laura Dolcini & Dr. María Carolina Ceriani

🧬Review in Viruses: How EV-A71 Evades the Immune System and Triggers Severe Complications

Enterovirus A71 (EV-A71) causes Hand-Foot-and-Mouth Disease but can lead to severe neurological issues and fatal pulmonary edema – especially in infants.

A valuable resource for understanding viral immune evasion and immunopathology.

👉 Read the full article: https://www.mdpi.com/1999-4915/17/12/1540

The Host Immune Response to Enterovirus A71 (EV-A71): From Viral Immune Evasion to Immunopathology and Prognostic Biomarkers of Severe Disease—A Narrative Review Enterovirus A71 (EV-A71) is a critical global pathogen, primarily causing Hand-Foot-and-Mouth Disease (HFMD) but frequently leading to severe neurological complications, including fatal neurogenic pulmonary edema (PE). This review elucidates the complex interplay between viral pathogenesis and the h...

Bluetongue virus has 10 RNA segments. How do they assemble? This study shows they interact sequentially (smallest to largest) through RNA-RNA interactions – independent of viral proteins NS2 and VP6. A new look at segmented genome packaging.

👉 https://www.mdpi.com/1999-4915/18/4/406

Visualization of Bluetongue Virus RNA Segment Networks in Infected Cells: Multipartite Genomic RNA Assortment Is Independent of Viral Proteins NS2 and VP6 Bluetongue virus (BTV), with a genome of ten double-stranded RNA segments (S1–S10), is an emerging animal pathogen causing major economic losses in livestock worldwide. BTV replication involves RNA-RNA and RNA–protein interactions, with RNA-binding proteins, VP6 and NS2 playing key roles in geno...

📢 New in Viruses: A narrative review on the immunopathogenesis of Long COVID – exploring persistent viral antigens, chronic immune activation, autoimmunity, endothelial dysfunction, and organ-specific mechanisms. A conceptual framework to guide future research.

👉 https://www.mdpi.com/1999-4915/18/4/458

Integrative Insights into the Immunopathogenesis and Organ-Specific Immunological Mechanisms of Long COVID: A Narrative Review Long COVID (LC), also referred to as post-acute sequelae of SARS-CoV-2 infection, is characterized by persistent symptoms originating 3 months following acute COVID-19, lasting for at least two months and frequently affecting individuals who initially experienced mild to moderate disease. The clinic...

📢 New Special Issue in Viruses: Antiviral Agents and Peptides – Discovery, Mechanisms, and Therapeutic Applications. Guest-edited by Dr. Xue Zhi Zhao. Original research and reviews are welcome on antiviral compounds, peptide-based drugs, resistance mechanisms, and host-directed therapies.

👉 https://www.mdpi.com/journal/viruses/special_issues/182DFYY99E

Antiviral Agents and Peptides: Discovery, Mechanisms, and Therapeutic Applications Special Issue in journal Viruses: Antiviral Agents and Peptides: Discovery, Mechanisms, and Therapeutic Applications

📢 Genomic epidemiology of SARS‑CoV‑2 in Ukraine (May 2022 – March 2024) – despite war and limited resources, researchers tracked Omicron dynamics (BA.5 → XBB → JN.1), identified multiple international introductions, and reported a CFR of 0.46%–1.74%.

👉 https://www.mdpi.com/1999-4915/17/7/1000

Genomic Epidemiology of SARS-CoV-2 in Ukraine from May 2022 to March 2024 Reveals Omicron Variant Dynamics In Ukraine, SARS-CoV-2 detection and national genomic surveillance have been complicated by full-scale war, limited resources, and varying levels of public health infrastructure impacted across the country. Following the Spring of 2022, only a paucity of data have been reported describing the preval...

📢 AI and machine learning for infectious disease management – a scoping review in Viruses highlights the potential of Explainable AI and ensemble learning for surveillance, diagnosis, and prognosis. A practical workflow is proposed to guide clinical implementation.

👉 https://www.mdpi.com/1999-4915/17/7/882

Machine Learning and Artificial Intelligence for Infectious Disease Surveillance, Diagnosis, and Prognosis Advances in high-throughput technologies, digital phenotyping, and increased accessibility of publicly available datasets offer opportunities for big data to be applied in infectious disease surveillance, diagnosis, treatment, and outcome prediction. Artificial intelligence (AI) and machine learning...

Oropouche virus is spreading across Latin America, but little is known about it. This study followed an infected traveler for 177 days and found that viral RNA cleared from serum within 15 days, but persisted in urine for 1 month, semen for 3 months, and whole blood for 4 months – with evidence of active replication throughout.

👉 https://www.mdpi.com/1999-4915/17/6/852

Persistence and Active Replication Status of Oropouche Virus in Different Body Sites: Longitudinal Analysis of a Traveler Infected with a Strain Spreading in Latin America An unprecedented outbreak of Oropouche virus (OROV) is occurring in the Americas, characterized by thousands of confirmed cases and a wide geographical spread, including areas outside the Amazon Basin. Little is known about this neglected arbovirus regarding its pathophysiological aspects and potent...

📢 From Viruses: A review on Culex-transmitted diseases (Japanese encephalitis, West Nile virus) and the potential of Wolbachia-based control strategies. As Culex mosquitoes expand into new regions due to climate change, understanding vector–pathogen interactions is more important than ever.

👉 https://www.mdpi.com/1999-4915/16/7/1134

Culex-Transmitted Diseases: Mechanisms, Impact, and Future Control Strategies using Wolbachia Mosquitoes of the Culex genus are responsible for a large burden of zoonotic virus transmission globally. Collectively, they play a significant role in the transmission of medically significant diseases such as Japanese encephalitis virus and West Nile virus. Climate change, global trade, habitat tr...

A six-year (2018–2024) analysis of seasonal influenza in Shenzhen shows how COVID-19 NPIs disrupted circulation—sharp decline during the pandemic, then a strong rebound. Genetic divergence from vaccine strains and key antigenic drift events in H3N2 and B/Victoria were also observed.

👉 https://www.mdpi.com/1999-4915/17/6/798

Analysis of Epidemiological and Evolutionary Characteristics of Seasonal Influenza Viruses in Shenzhen City from 2018 to 2024 The SARS-CoV-2 pandemic and the implementation of associated non-pharmaceutical interventions (NPIs) profoundly altered the epidemiology of seasonal influenza viruses. To investigate these changes, we analyzed influenza-like illness samples in Shenzhen, China, across six influenza seasons spanning 2...