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TRC has over 40 years specialised in the production of quality products for innovative research.
08/13/2026
Many factors influence the reported API potency result.
From sample preparation and reference standards to instrument performance and method validation, every stage of the assay can affect the final result. Understanding these sources of variation is essential for generating accurate and reliable potency data.
💡Our latest application note explores sources of systematic bias in LC–UV potency assays and practical strategies to minimise them.
⬇️ Download the application note: https://ow.ly/EvhX50ZxGO6
Our quality reference standards can help your lab to meet strict regulatory limits on NDSRIs and small molecule nitrosamines around the world.
We offer:
✔️650+ NDSRI compounds for major therapeutic areas (e.g. neuroscience, oncology, metabolic disorders),
✔️90+ small molecule nitrosamine reference materials (including NDMA, NDEA, NMBA and DIPNA),
✔️Active development pipelines (150+ NDSRIs in progress and new products released monthly),
✔️Rapid, responsive custom synthesis,
✔️Varied formats, including neats, ready-to-use solutions, plus native and labelled standards,
✔️Multiple quality levels to suit the nature of your work.
Discover more: https://ow.ly/VhSI50ZxHAW
⚠️In nitrosamine analysis, matrix interference can obscure out-of-specification results, risking the release of noncompliant batches.
Our free webinar - “Trace-Level Quantification of Nitrosamines in Pharmaceuticals: Pitfalls and Solutions” - features an essential case study on how to overcome such matrix effects.
By watching, you can learn more about relevant practical strategies, including:
âś…use of internal stable isotope labelled standards,
âś…modification of chromatography conditions and sample dilution to reduce matrix load
âś…different calibration approaches, including external calibration and standard addition.
Watch now: https://ow.ly/yxAb50Zv3Nc
Despite being at the top of the pharmaceutical agenda, there are still plenty of unresolved questions about how we control nitrosamines.
đź’ˇOur free webinar - featuring five experts from industry, academia and regulatory science - is an essential guide to the science, regulation and practical management of nitrosamines.
The discussion covers:
✔️how risk assessment and toxicology inform nitrosamine control and regulatory decisions,
✔️why changes to ICH M7 may affect the product lifecycle, and
✔️how method development, validation and standards underpin testing confidence.
Watch the panel discussion on demand now: https://ow.ly/Q3Z050Zv7VF
07/30/2026
What you separate determines what you measure.
đź’ˇ Our newest application note highlights practical strategies for improving method performance and generating more reliable potency measurements.
➡️ Swipe through for key insights and download the full application note here: https://ow.ly/kHno50Zu82C
07/28/2026
đź“š Spotlight
How do nitrosamines damage DNA?
Researchers at Lincoln University College recently investigated N-nitroso-ketamine (NNK), a nitrosamine impurity that can form from ketamine hydrochloride.
DOI: 10.21203/rs.3.rs-10048801/v1​‌
👇This graphic highlights the pathway from metabolic activation and DNA alkylation to mutations and potential carcinogenesis.
We're pleased to see that the study utilised a TRC N-Nitroso-Ketamine reference standard, supporting ongoing nitrosamine research and analytical method development.
🔬 Explore our nitrosamine research and reference materials:
https://ow.ly/xmCp50ZscCk
The latest US duloxetine recall is another reminder of the importance of effective nitrosamine control. Recent testing identified N-nitroso-duloxetine above FDA-recommended limits, resulting in the recall of thousands of bottles. đź’Š
▶️ Watch our video to learn more about the challenges of nitrosamine risk management
Explore our nitrosamine reference materials that can support your testing workflows:
https://ow.ly/Wm3a50ZqNuF
Discover how our brand new Organic Chemistry Synthesis Centre of Excellence in Toronto is helping us to serve our customers even better.
In this short video, LGC's President & CEO, Joydeep Goswami explains how the award-winning TRC complex enables:
âś…more efficient ways of working,
âś…faster response times,
âś…operational flexibility,
âś…high-quality solutions, and
âś…expanded services.
This in turn empowers our customers to deliver more solutions to the world's most pressing problems: like safeguarding the environment and protecting people's wellbeing.
👇Find out more about what we can do for you: https://ow.ly/SBpp50Zmpgo
07/15/2026
đź’Facing challenges with nitrosamine impurities?
đź’ˇDiscover how our latest poster, "NDSRI Risk Assessment and Trace-Level Analysis of N-Nitrosamines," can help. Learn about a robust UPLC/MS/MS method for detecting N-nitroso-sertraline in sertraline drug substances and products, developed through a unique collaboration between LGC Standards and Waters Corporation.
⬇️Download now to see how you can strengthen safety and compliance in your workflow: https://ow.ly/KxjG50ZmNSv
07/14/2026
📢 New nitrosamine reference materials now available
👇We are pleased to introduce four new additions to our Rivaroxaban API family portfolio, further expanding our range of nitrosamine reference materials available to support pharmaceutical analysis and research.
Explore the new Rivaroxaban launches: đź”— https://ow.ly/ckcr50Zmon5
Browse all newly released nitrosamine reference materials: đź”— https://ow.ly/PvsN50Zmona
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