Transcriptomic Solutions

Big News! 🎉 Our research featured in Nature!Thrilled to share that our work on the gut microbiome’s link to fibromyalgia, in collaboration with Amir Minerbi (clinician) and Nick Brereton (biologist), has been recognized by Nature. This project is a real team effort, blending clinical expertise, biology, and computational techniques to uncover key bacterial players in chronic pain. It’s exciting to see our efforts featured by one of the most respected journals!

Check it out here: https://www.nature.com/articles/d41586-024-03006-z

The gut microbiome and chronic pain Pain from conditions such as endometriosis could be alleviated if the gut’s resident bacteria can be understood and tamed.

🚀🔬 Big news in space biology!

I’m excited to share our latest study, just published in npj Biofilms and Microbiomes, with my partner in crime Nick Brereton, McGill University and a fantastic team of international scientists, including those at !

Link: https://www.nature.com/articles/s41522-024-00545-1

Our research, part of the Nature Portfolio package, “The Second Space Age: Omics, Platforms, and Medicine across Space Orbits”, offers new insights into how space travel affects the gut microbiome:

🔍 Space travel significantly changes the gut microbiome, which could impact immune function and metabolism in space.

🌑 This is crucial for the success of long-term space missions, such as a Moon base or Mars expedition, and helps ensure astronaut health during extended space travel.

A huge thank you to everyone involved in this groundbreaking study from institutions around the world, including McGill University, NASA Ames, Harvard, Cornell, MIT, Blue Marble Space Institute

The journey continues as we explore the next frontier of human health in space and on Earth!

Spaceflight alters host-gut microbiota interactions - npj Biofilms and Microbiomes The ISS rodent habitat has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these physiological responses can involve the microbiome on Earth, host-microbiota interactions du...

Gut bacteria associated with chronic widespread pain for first time : Med e-News

Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting - Nature Communications Dietary glycans are a major driver of the human gut microbiota composition. Here, the authors apply next-generation metabolic labeling coupled with fluorescence-activated cell sorting to identify and isolate gut bacteria consumers of dietary glycans in human stool samples, linking bacteria to the gl...

More metagenomics from TS researchers investigating the gut microbiome of patients with fibromyalgia:

https://publications.mcgill.ca/medenews/2019/06/20/gut-bacteria-associated-with-chronic-widespread-pain-for-first-time/

https://nouvelles.umontreal.ca/en/article/2019/06/19/scientists-discover-gut-bacteria-is-associated-with-chronic-pain/

https://journals.lww.com/pain/Abstract/publishahead/Altered_microbiome_composition_in_individuals_with.98647.aspx

Gut bacteria associated with chronic widespread pain for first time : Med e-News

Interview at Radio Canada by Manu Gonzalez discussing Anchor 16S rRNA gene microbial profiling on the international space station.

Déterminer les bactéries dans la Station spatiale internationale Des bactéries dans l’espace? Une nouvelle méthodologie génomique a permis de révéler la présence d’un écosystème bactérien à bord de la Station spatiale internationale (SSI). On doit cette découverte à une équipe de scientifiques de l’Université de Montréal et de l’Université...

Metagenomics article from TS researchers investigating space station modules, or how rocket passengers party in space👨‍🚀🐦🐁💐

ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples - Gonzalez - - Environmental Microbiology - Wiley Online Library Environmental MicrobiologyEarly View EMI ‐ Research article Open Access ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples Emmanuel Gonzalez Canadian Centre for Computational Genomics, McGill University and Genome Quebec Innovation Centre, Montréal,...

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0432-5

Trees, fungi and bacteria: tripartite metatranscriptomics of a root microbiome responding to soil contamination One method for rejuvenating land polluted with anthropogenic contaminants is through phytoremediation, the reclamation of land through the cultivation of specific crops. The capacity for phytoremediation crops, such as Salix spp., to tolerate and even flourish in contaminated soils relies on a highl...

https://mcgill.ca/newsroom/channels/news/plants-fungi-and-bacteria-work-together-clean-polluted-land-286247

Plants, fungi and bacteria work together to clean polluted land Highly complex interactions among roots, fungi and bacteria underlie the ability of some trees to clean polluted land, according to a novel study by bioinformatics and plant-biology experts from McGill University and Université de Montréal. Fast-growing trees, such as willows, are known to tolerat...

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00366/full research with the Shanghai Botanical Gardens

The Response of a 16S Ribosomal RNA Gene Fragment Amplified Community to Lead, Zinc, and Copper Pollution in a Shanghai Field Trial Industrial and agricultural activities have caused extensive metal contamination of land throughout China and across the globe. The pervasive nature of metal pollution can be harmful to human health and can potentially cause substantial negative impact to the biosphere. To investigate the impact of....

http://www.plantphysiol.org/content/171/1/3

Comparative Transcriptomic Approaches Exploring Contamination Stress Tolerance in Salix sp. Reveal the Importance for a Metaorganismal de Novo Assembly Approach for Nonmodel Plants

Transcriptomic Solutions