Cordat Lab
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Page under construction These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance.
Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermato
03/05/2026
Welcome to Mathieu Ruyssckaert and Celebration lunch for Grace's manuscript! The ramens were delicious on this freezing day!
03/05/2026
Here is our latest publication in eLife!
https://elifesciences.org/articles/108253
Congratulations to Grace for her hard work on this project👏
SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
10/01/2025
Welcome to undergraduate research student Lynzae Ecaldre!
10/01/2025
Here is our newest publication! Congratulations to first author Priyanka Mungara and all authors:
Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations Summary: Mouse lines carrying Ae1 L919X or R607H knock-in variations that mimic human distal renal tubular acidosis (dRTA) display urinary sodium waste, as seen in some patients with dRTA, and upregulation of tight junction proteins claudin 4 and 10b, when exposed to a salt-depleted acid challenge.
10/01/2025
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03/18/2025
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Coalition for Research Excellence – Coalition pour l'excellence en recherche – Contact: [email protected] Welcome to the CORE-COEUR : the Coalition for Research Excellence in Canada is an informal non-partisan coalition of researchers agreed that a robust research ecosystem is in the common interest and should be a strategic priority for the next Canadian Parliament and federal government. We are unitin...
04/08/2024
Priyanka and Grace had a great time at the American Physiological Society Meeting in Long Beach California last week!
Check out our new open-access publication in Heliyon journal
https://doi.org/10.1016/j.heliyon.2023.e22280
Congratulations to Rawad and Grace for their work!
07/12/2022
Congratulations to Dr. Shahid AKM Ullah for defending his Thesis! Well done Shahid!
07/12/2022
Patio time with the lab!
09/23/2021
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Our Story
Research in the Cordat’s lab is focused on trafficking of membrane proteins in cells, with a particular emphasis on bicarbonate transporters. These transporters are expressed in many organs where they participate in acid-base homeostasis and electrolyte balance. Any imbalance of plasma bicarbonate homeostasis alters a number of physiological processes, including homeostasis of oxalate, a component of 80 % of kidney stones, indirect regulation of water reabsorption, plasma pH homeostasis, bile duct function, spermatogenesis, vision, hearing or cardiovascular function.
The Cordat’s lab has worked for many years on the kidney anion exchanger 1 (kAE1) protein. kAE1 mutations can be inherited and can induce a kidney disease called distal renal tubular acidosis (dRTA). This disease causes failure to thrive, muscle weakness and renal calculi. We currently work on further understanding the function and regulation of kAE1 but also of other bicarbonate transporters from the SLC26A gene family.
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