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Home | Awakeningelixirs.com Family owned and operated since 2019. Awakening Elixirs is committed to providing a variety of high quality homeopathic products at the lowest price possible. With the exception of our honey which is sourced from a local farmer here in Arizona, my wife Sarah and I make all of our products. ...
This is your reminder to take your daily dose of elderberry 🙏🏼😊
👨🏼⚕️Dr. Patrick Flynn on Cytokine storm
https://youtu.be/KxXyCyr5OAs
👩🏻⚕️Dr. Ana Jackson on Cytokine storm
https://www.facebook.com/100009908595379/posts/1115319318808344/?d=n
Larken Bunce - Vermont Herbalist 🌿:
“I’ll do my best to answer here, but it’s going to take a wee booklet of space. To my knowledge and that of other herbalists responding to this same concern, there's no evidence clinically or via research that elderberry has ever caused a cytokine storm (which, for anyone reading who’s not aware, is an uncontrolled inflammatory response which damages tissue--here we mean lung tissue). This is more common in those with strong immunity, e.g. “young, healthy” folks. There is evidence that elderberry extract can increase certain pro-inflammatory cytokines, the same ones involved in cytokine storms. Cytokine storms were a feature of H1N1 influenza and elevated levels of two of these same cytokines (IL-6 and IL-8) were identified in some folks with severe cases. So, if we’re extrapolating theoretically (as the original author of the post that started this concern was doing), we might be concerned, as cytokine storm features in severe cases of COV IT 1 nine. It’s good to be critical and have nuance in our use of herbs, which I believe is all she was advocating for. But, let’s take another look: while cytokine storm *was* a feature of H1N1, at least here in Vermont it was also an instance where a huge amount of elderberry was consumed indiscriminately by a self-treating population. In fact, it gained a lot of popularity around that time because of some well-timed research re: direct anti-viral activity. But, to my knowledge none of us practicing identified a relationship between elder and worsening symptoms. Could we have missed it? Of course. But, what we did hear was how much folks felt like elder helped them stay well or get better faster than other family members or co-workers, etc. As I mentioned and the article pointed out, research suggests elderberry can indeed upregulate some of these pro-inflammatory messengers and this is part of its value in improving immune response. But, there's also research suggesting it reduces those same cytokines, acting as an anti-inflammatory.
So, as you said, it’s likely most accurate to say it’s a *modulator* of cytokine expression or activity, making it generally safe and helpful *for many*, though not all folks. The bottom line is that herbs and humans and our interactions are complex. While using research to ask better questions and be more specific in our use, we also want to look at clinical experience. Again, to my knowledge, no one has seen or suspected this cause and effect relationship (elderberry use = cytokine storm in viral infection) clinically. I personally am using elderberry and recommending it to my family and friends for prevention right now, along with other herbs and approaches. However, if I were to get sick and began to run a fever (sign of more pro-inflammatory cytokines), I would stop elderberry and move towards more appropriate herbs to address fever management (not suppression--like yarrow, elder flower, peppermint) and, perhaps work on keeping mucus thin with aromatic herbs like garlic, ginger, horseradish and elecampane. Licorice can be a strong anti-inflammatory, along with the other herbs I mentioned. This is NOT meant to be taken as “how to treat COV IT 1 nine”, I’m just giving you my personal approach for ME, right now. (I’d also call my doc and see if I need to get tested and stay the heck home, which I’m very privileged to be able to do.) The point is that I would use elder when it’s appropriate and most effective and then shift to other herbs when they are more indicated. Not because I’m worried that elderberry will cause harm, but because other herbs will likely work better at different stages of illness.
And, regarding the original article raising alarm, the author’s original concern, I believe, was more directed at using caution with folks who have auto-immune conditions, which also involve excess inflammation driven by these and other pro-inflammatory cytokines. Many herbalists have not seen worsening of inflammation/symptoms with elderberry, but a number of individuals do say they’ve had this experience and some clinicians have also seen it, including that author. When COV IT 1 nine came on the scene and everyone was going wild for elderberry all over the interwebs, the author shared her old article to make sure folks know that maybe elderberry isn’t for everyone in every situation, esp. not some folks with auto-immune conditions, or when it’s time to choose other more specific plants. Then things went, shall we say, viral. Sending you health and hope you and your family are well!”
Dr. Ana Jackson:
Is Elderberry safe to take during a viral infection? Will it contribute to a cytokine storm??
Note: This is information for you. As always, please speak to your own physician/naturopath around herbal use for yourself or your family.
There has been some in-vitro studies that DO show elderberry can increase inflammation (cause a cytokine storm) but these are in-vitro--meaning they are done in labs in test tubes which is very different than how the human body operates!
There is a TON of research on the safety profile of Elderberry and its efficacy at reducing the symtoms and severity of upper respiratory infections. So much so that there has been a meta-analysis published in 2018 concluding: "Supplementation with elderberry was found to substantially reduce upper respiratory symptoms." Additionally, "these findings present an alternative to antibiotic misuse for upper respiratory symptoms due to viral infections, and a potentially safer alternative to prescription drugs for routine cases of the common cold and influenza."
Source: Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361-365. doi:10.1016/j.ctim.2018.12.004
In a double-blind, placebo controlled study looking at sixty patients, "symptoms were relieved on average 4 days earlier and use of rescue medication was significantly less in those receiving elderberry extract compared with placebo" and did not cause any adverse effects.
Source: https://journals.sagepub.com/doi/10.1177/147323000403200205
There is overwhelming evidence showing that Elderberry is both safe AND reduces the severity of upper respiratory infections by blocking viral uptake. Yes, there are 3 in-vitro studies showing it can increase cytokines but we have many more human studies that show this is not the case.
This is the problem with studies and science. People will take 1-2 studies and make a conclusion instead of looking at the WHOLE body of evidence that clearly shows Elderberry (Sambucus nigra) is safe and does not contribute to a cytokine storm in humans.
Bottom line--I'm taking Elderberry 🙂
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Don’t forget your daily dose of elderberry! 💜
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Elderberry extract seems to offer an efficient, safe and cost-effective treatment for influenza. These findings need to be confirmed in a larger study."
https://www.ncbi.nlm.nih.gov/m/pubmed/15080016/?i=2&from=elderberry+syrup
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056848/
Anti-influenza virus effects of elderberry juice and its fractions. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/22972323
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/9395631
Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak... - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/27023596
The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/11399518
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848651/
Elderberry flavonoids bind to and prevent H1N1 infection https://www.ncbi.nlm.nih.gov/m/pubmed/19682714/
Anti-influenza activity with Elderberry
https://www.sciencedirect.com/science/article/abs/pii/S1756464619300313?via%3Dihub
Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication (Coronavirus)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899428/pdf/1746-6148-10-24.pdf
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