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San Pablo derives its name from the Spanish for Saint Paul, referring to the local patron saint, Paul the First Hermit. It was previously known as San Pablo de los Montes, which translates to "Saint Paul of the Mountains" in Spanish.
San Pablo's earliest historical record dates back to pre-Spanish times when four large barrios bounded by Mount Makiling composed of settlements, the most prominent of which was "Sampalok" (Sampaloc). In 1571, the first Spanish troops under Captain Juan de Salcedo arrived in the upland village of Sampaloc. It was noted by Father Joaquin Martinez de Zuñiga that its original inhabitants were Aetas and were ruled by four chieftains.
San Pablo became a parish in 1586, and then a municipality in 1647, and was renamed "San Pablo de los Montes" in honor of Saint Paul the First Hermit.

The original Name is "Luis y Ana" And later became the town of Luisiana. It was only on April 3, 1854, that ecclesiastical independence was granted to San Luis by the Governor-General (the Marqués de Novaliches) with the corresponding approval from the Archbishop of Manila, having Don Marcos Bartolomé as its first interim parish priest. Because of the role of Don Luis Bernárdo, which was then regarded as the Father of Luisiana, and his wife Doña Ana, the town was named 'Luis y Ana', later changed to 'Luisiana'. The town's Catholic church, which is dedicated to Our Lady of the Rosary, was established in 1854 but burned down in 1872 before being rebuilt.
During the 17th century, there was an area of land in Laguna known as Terreno De Nasunog or Lupain ng Nasunog, it is a part of Majayjay, Laguna.. The name "Luisiana" was given in honor of Don Luis Bernardo and his wife Doña Ana Esperanza, who fought for the Independence of Luisiana.
In 1948, Visita de Luisiana gained civil independence from Majayjay. Today Luisiana is still a progressive Town and yearly Celebrates "Pandanan" Festival. The Town was Called "Little Baguio of Laguna" Because of its climate and "Pandan Capital of Laguna" Because of the Pandan Trees all over Luisiana.