Dityatev Lab

Retweeted from Rahul Satija

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at http://satijalab.org/scgd. Please RT/spread the word!

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Supply chain logistics?

This new review out of the University of Manchester () discusses the role of the Golgi complex in production and maintenance.

Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance | Journal of Cell Science | The Company of Biologists John Hellicar, Nicola L. Stevenson, David J. Stephens, Martin Lowe; Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance. J Cell Sci 1 January 2022; 135 (1): jcs258879. doi: https://doi.org/10.1242/jcs.258879

Do miss this very timely article on Laughter Therapy: A humor-induced hormonal intervention to reduce stress and anxiety -

Laughter therapy: A humor-induced hormonal intervention to reduce stress and anxiety Prolonged pharmacological interventions have detrimental health consequences by developing drug tolerance or drug resistance, in addition to adverse d…

Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges and links to ECM

Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges - PubMed Hevin is secreted by astrocytes and its synaptogenic effects are antagonized by the related protein, SPARC. Hevin stabilizes neurexin-neuroligin transsynaptic bridges in vivo. A third protein, membrane-tethered MDGA, blocks these bridges. Here, we reveal the molecular underpinnings of a regulatory n...

A study on the mechanisms of synaptic insulin resistance is online - thanks to the ENERGI consortium and our collaboration with the Michael Kreutz group:

Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease - Translational Neurodegeneration Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It has been proposed that neuroinflammation might be an interven...

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And this single cell proteomics paper is now accepted and live at Analytical Chemistry!

Patch-Clamp Proteomics of Single Neurons in Tissue Using Electrophysiology and Subcellular Capillary Electrophoresis Mass Spectrometry Understanding of the relationship between cellular function and molecular composition holds a key to next-generation therapeutics but requires measurement of all types of molecules in cells. Developments in sequencing enabled semiroutine measurement of single-cell genomes and transcriptomes, but ana...

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Targeting the Molecular & Cellular Pillars of Human Aging with Exercise

Jorming Goh et al. FEBS J.

FEBS Press Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of ...

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Great new review! Extracellular matrix and its therapeutic potential for .

Extracellular matrix and its therapeutic potential for cancer treatment - Signal Transduction and Targeted Therapy The extracellular matrix (ECM) is one of the major components of tumors that plays multiple crucial roles, including mechanical support, modulation of the microenvironment, and a source of signaling molecules. The quantity and cross-linking status of ECM components are major factors determining tiss...

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A new set of CRISPR plasmids is available Kim Yong-Sam's lab! This efficient CRISPR editing system uses a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus.

Addgene: Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs delivered by adeno-associated virus. Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Copy number variants in neurexin genes: phenotypes and mechanisms

Copy number variants in neurexin genes: phenotypes and mechanisms - PubMed Neurexins are central to trans-synaptic cell adhesion and signaling during synapse specification and maintenance. The past two decades of human genetics research have identified structural variations in the neurexin gene family, in particular NRXN1 copy number variants (CNVs), implicated in multiple...

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states - PubMed Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but whether they adopt deleterious features consistent with inflammatory reactive states remains incompletely resolved. To identify inflammatory reactive features in ALS human induced pluripotent stem cell (hiPSC)-de...

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Lab Christmas present :) Published our last paper on the effects of aging on hippocampal interneuros. Interesting s*x specific effects and impact on GluN2B receptors. Great work by
, Pat Klimczak and the rest of the team!

Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus Changes in the physiology, neurochemistry and structure of neurons, particularly of their dendritic spines, are thought to be crucial players in age-related cognitive decline. One of the most studied brain structures affected by aging is the hippocampus, known to be involved in different essential c...