Brain Health Registry

Brain Health Registry

A groundbreaking online project developed by UCSF researchers to speed up clinical trials seeking treatments for Alzheimer's, Parkinson's, PTSD and other brain diseases and disorders.

The Brain Health Registry - led by top medical researchers at UCSF and other leading scientific institutions - is a groundbreaking web-based project designed to accelerate clinical trials seeking treatments for Alzheimer’s, Parkinson's, depression, PTSD, and other brain disorders. Participation is safe, easy and free. Go to to sign up today.

Marine Molecules With Therapeutic Potential Against Alzheimer's Disease

"These are two marine molecules, meridianine and lignarenone B, able to alter the activity of GSK3B activity, a protein associated with several neurodegenerative diseases." A study has discovered two potential candidates to treat Alzheimer’s disease. The two marine molecules, meridianine and lignarenone B, can alter the activity of GSK3B activity, a protein linked to several neurodegenerative diseases.

The analysis of copper levels in blood facilitates diagnosis of Alzheimer's disease

"The analysis of copper levels in blood facilitates diagnosis Alzheimer's disease." In biology, it is well-known that every living organism is triggered by the DNA that encodes various protein molecules, which in turn perform all the necessary biological functions, and it might seem that nothing else is needed to sustain the life of an organism.

Blood Clotting and Alzheimer’s

"Fibrinogen, a key blood coagulation component, is involved in a cascade of events at both molecular and cellular events which lead to the loss of memory storage neurons within the brain." Alzheimer’s disease is a condition in which the individual suffers the loss of cognitive faculties such as thinking, logic, and judgment.

How flashing lights could treat Alzheimer’s disease

"Now a spate of new studies suggests that an electrical, rather than chemical, approach to treatment may be the answer." Could a potential new treatment for the most common form of dementia be delivered by simply watching television?

COVID-19’s hidden victims, Alzheimer's patients in nursing homes

"Nearly 50% of all nursing home residents live with Alzheimer's or dementia." Nursing homes account for almost a third of coronavirus deaths and patients with Alzheimer’s disease are especially vulnerable.

MRI monitoring of brain glucose levels may help detect Alzheimer's disease – Physics World

"Abnormal glucose uptake and clearance in the brain’s lymphatic system are a hallmark of early Alzheimer’s disease." Dynamic glucose-enhanced MRI detects altered glucose uptake and clearance in the brains of mice with Alzheimer’s disease

Researchers link high calcium levels in mitochondria to neuronal death in Alzheimer's disease

"High calcium levels in the mitochondria cause oxidative stress, and the death of neurons via apoptosis," says Calvo-Rodriguez. "We propose that by blocking the neuronal mitochondrial calcium uniporter we can prevent cell death and impact disease progression." Their work suggests targeting calcium entry to the mitochondria could be a promising new therapeutic approach in Alzheimer's disease. For the first time, using a mouse model of Alzheimer's disease, scientists have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain. This relationship was previously documented in cell culture, but seeing this phenomenon in living mice makes it m...

Simple molecular reagents to treat Alzheimer's disease

Professor Lim said, "This strategy is straightforward, time-saving, and cost-effective, and its effect is significant. We are excited to help enable the advancement of new therapeutic agents for neurodegenerative disorders, which can improve the lives of so many patients." Sometimes the most complex problems actually have very simple solutions. A group of South Korean researchers reported an efficient and effective redox-based strategy for incorporating multiple functions into simple molecular reagents against neurodegenerative disorders. The team developed redox-acti...

Study using human brain tissue shows herpes link to Alzheimer's - STAT

"The new research, published in Science Advances, is the first to directly show in a lab model (rather than through circumstantial evidence from human studies) that the herpes simplex virus HSV-1 might cause Alzheimer’s: Human brain-like tissue infected with the virus became riddled with amyloid plaque-like formations — the hallmark of Alzheimer’s. It also developed neuroinflammation and became less effective at conducting electrical signals, all of which happen in Alzheimer’s disease." Human brain tissue infected with herpes simplex virus became riddled with amyloid plaque–like formations — the hallmark of Alzheimer’s.

More berries, apples and tea may have protective benefits against Alzheimer's

"The epidemiological study of 2,800 people aged 50 and older examined the long-term relationship between eating foods containing flavonoids and risk of Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD). While many studies have looked at associations between nutrition and dementias over short periods of time, the study published today in the American Journal of Clinical Nutrition looked at exposure over 20 years." Older adults who consumed small amounts of flavonoid-rich foods, such as berries, apples and tea, were two to four times more likely to develop Alzheimer's disease and related dementias over 20 years compared with people whose intake was higher, according to a new study led by scientists at the Jean...

Study of lipid metabolism in neurons may offer therapeutic possibilities for neurodegenerative diseases

What might our metabolism of fats have to do with neurodegenerative disease? Harvard scientists investigate.

“We are cautiously optimistic,” Farese said. “Perhaps targeting lipid abnormalities provides a new therapeutic angle for some diseases of neurodegeneration.” For immediate release: April 13, 2020 Boston, MA – Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in …

Nanodevices for the brain could thwart formation of Alzheimer's plaques

"We've taken building blocks from nanotechnology and biology to engineer a high-capacity 'cage' that traps the peptides and clears them from the brain." -- Elena Rozhkova, scientist, Center for Nanoscale Materials Researchers designed a nanodevice with the potential to prevent peptides from forming dangerous plaques in the brain in order to halt development of Alzheimer's disease.

These Foods Can Increase Your Alzheimer's Risk

The relationship between diet and Alzheimer's disease is often overlooked. This article summarizes some of what scientists have discovered about this! New research finds that it’s not only what you eat, but also how you combine certain foods that can increase your risk of developing Alzheimer’s and other forms of dementia in later life. The foods most strongly associated with this risk were starches like potatoes, sugary snacks, alcohol, and p...

HudsonAlpha scientists collaborate to uncover a gene that doubles the risk of developing several neurodegenerative diseases

Scientists at the HudsonAlpha Institute for Biotechnology, the University of California, San Francisco (UCSF), and the University of Alabama at Birmingham (UAB), have identified a new risk factor for multiple neurodegenerative diseases.

"Finding evidence for a risk factor that contributes to multiple neurodegenerative diseases is exciting," said Richard M. Myers, PhD, HudsonAlpha president and science director. "We already know that these diseases share some pathologies. This work shows that the underlying causes of those pathologies may also be shared." Scientists at the HudsonAlpha Institute for Biotechnology, the University of California, San Francisco (UCSF), and the University of Alabama at Birmingham (UAB), have identified a new risk factor for multiple neurodegenerative diseases.

New blood test for Alzheimer's developed

"We believe that, in the future, one very important use of our blood test will be for screening in primary care. We demonstrated this in one of the studies forming part of our article, in which we looked at patients in primary care with concerns about their failing memory," Blennow says.

"We also think the level of P-tau181 in blood plasma may be a very important marker to show and monitor the efficacy of the new drugs against Alzheimer's that are currently being developed," says Henrik Zetterberg. A new blood test for Alzheimer's disease has been developed under the leadership of researchers at the University of Gothenburg, Sweden. The method is based on measuring a specific variant of tau protein in ordinary blood samples, which makes the test relatively simple and cheap to perform.

Brain Health Registry Newsletter - April 2020 | Brain Health Registry

Check out our April 2020 newsletter: Alzheimer's Disease & Behavioral Changes One of the biggest issues in Alzheimer’s disease is the way it changes our behavior, for patients and their families and for doctors. At the Brain Health Registry, we are making efforts to understand these behavioral changes from a scientific viewpoint. From this understanding, doctors and resear...

Two views on Alzheimer's biomarkers: Eyeing changes in vision or pupils

"Pupillary response might be a new, noninvasive method that, combined with other biomarkers, identifies cognitively normal people who are at risk for Alzheimer’s early in the disease process, the authors concluded." Eye changes were associated with Alzheimer’s biomarkers and genetic risk scores in two NIA-supported studies, suggesting new ways detect early Alzheimer’s in cognitively normal people.

Discovery links glucose metabolism abnormalities to Alzheimer’s disease

"A new study, funded by the National Institutes of Health’s National Institute on Aging, is offering novel insights into how protein expressions can be altered during the course of Alzheimer’s disease. The research suggests proteins regulating glucose metabolism and the anti-inflammatory activity of brain immune cells are linked with Alzheimer’s pathology, and could point researchers toward new treatment and diagnostics." A new study, funded by the National Institutes of Health’s National Institute on Aging, is offering novel insights into how protein expressions can be altered during the course of Alzheimer’s disease. The research suggests proteins regulating glucose metabolism and the anti-inflammatory activity...

Gene-network Analysis a Valuable Resource for Understanding Alzheimer's Disease

"In a new study, researchers from Osaka University, Niigata University, and the National Center for Geriatrics and Gerontology have revealed genes that trigger specific changes in connections between proteins, called protein domain networks (PDNs), that are significantly associated with neurodegeneration in AD.

Network analysis is effective for identifying features of AD in humans, as well as identifying genes that control pathological changes in network properties. The researchers conducted network analysis of changes in PDNs to determine whether this process could be used to reveal genetic changes associated with AD pathology throughout the different stages of the disease." Researchers have unveiled a new way to identify genes implicated in neurodegeneration in Alzheimer’s disease.

How Managing Diet, Exercise, and Hearing Loss Lowers Alzheimer’s Risk

Great article on both the causes of Alzheimer's disease and how they can be managed! Research shows diet, exercise, and lifestyle choices can all contribute to lowering your risk for Alzheimer's disease. Here's what experts suggest.

For Alzheimer's Patients And Their Families, Coronavirus Can Mean Loving From Afar Efforts to keep coronavirus out of care facilities has left many Alzheimer's patients isolated from their families. Online contact is often the best option but it's not the same as an in-person visit.

Dr. Steven Sabat - Managing Anxiety and Depression During Quarantine - Being Patient

Great interview! Not only on managing mental health during quarantine, but also about managing dementia, patients and caretakers, more generally. Dr. Steven Sabat shares advice on managing feelings of depression and anxiety among people with dementia during quarantine life.

Scientists Discover New Neurodegenerative Disorder That May Provide Clues to Alzheimer's - Being Patient

“It’s intriguing to me that there’s some overlap with the pathogenesis of more common neurodegenerative adult diseases like Alzheimer’s in [which] we see that inappropriate activation of the microglia,” White said. “And so maybe, just maybe, there’s something we can learn from this ultra-rare neurodegenerative disorder which can help us better understand the devastating disease that is Alzheimer’s.” In a new study, researchers discovered a new neurodegenerative disorder that may help shed light on some of the causes behind Alzheimer's.

Caring for Someone with Alzheimer’s During the COVID-19 Outbreak

“There’s no perfect solution for anybody these days, but if you are a caregiver for someone with dementia in your home or in a facility, you are facing uncharted territory,” Tom Meuser, PhD, director of the Center for Excellence in Aging & Health at the University of New England, told Healthline. These 5 simple tips from experts can help caregivers navigate the complex and quickly changing environment of caring for people with Alzheimer's while social distancing.

Discovery of new biomarker in blood could lead to early test for Alzheimer's disease

For some time scientists have known that the APOE gene is highly correlated with Alzheimer's disease. Now, scientists have found another gene associated with Alzheimer's disease, called PHGDH.

"Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer's disease. The work could lead to the development of a blood test to identify individuals who will develop the disease years before they show symptoms." UC San Diego researchers discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer's disease. The work could lead to the development of a blood test to identify individuals who will develop the disease years before they show sympt...

‘A minute later, she forgets.’ Pandemic brings new challenges when a loved one has dementia.

'Singer said that her husband used to love watching the news, but she now tries to keep him away from it. He gets confused that things on TV are happening to him. “I tell him the coronavirus won’t happen to us, and I remind him that he’s safe, and that calms him,” Singer said. But she feels that he’s cognizant enough that he’s taking it in on some level. “We’re all nervous and afraid, and he intuits that. I never show him any fear, because he relies on me to keep him safe.”' Some caregivers are dealing with changes at home; others are unable to see their family members.

Personality May Predict Changes in Alzheimer's-Related Brain Areas

It's anecdotal knowledge that personality changes coincide with Alzheimer's disease. This is research that helps to understand more specifically what about people tends to change. The more compliant you are, the more your mental health may suffer.

Council Post: Latinas In STEM Lead The Way In The Fight Against Alzheimer's Disease

"The main focus of the MAPP is to identify some of the earliest biological and cognitive changes associated with the predisposition and risk to develop Alzheimer’s disease, with the ultimate goal of informing future clinical trials and early interventions.

To accomplish this goal, the team works with the world’s largest family with a single genetic mutation leading to Alzheimer’s disease before the age of 40. This is a very rare group, as more than 95% of the individuals with Alzheimer’s disease are older than 65. The family with the mutation resides in Antioquia, Colombia, and has approximately 6,000 members, including roughly 1,200 carriers of the mutation, known as the Paisa mutation." Advances in biomarker research and early detection paradigms are being developed by a group of Latinas in science, technology, engineering and math (STEM) from the Massachusetts General Hospital and Harvard Medical School.

Immune Reaction Is "Fuel to the Fire" of Alzheimer's Disease

The scientists hope that a better understanding of these processes might also lead to the development of new therapeutic approaches. This is because the accumulation of Aß probably begins decades before the first symptoms of disease appear. Early intervention may be able to slow down this fateful process. "This might make it possible to treat Alzheimer's disease preventively in the future, so that there is no impairment of mental performance in the first place," hopes Prof. Heneka. An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it

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