National Cancer Institute

National Cancer Institute

NCI is the lead federal agency for cancer research. Connect with us here, call us at 1-800-4-CANCER, or visit us at www.cancer.gov.

Mission: NCI leads, conducts, and supports cancer research across the nation to advance scientific knowledge and help all people live longer, healthier lives. For more information about NCI, visit us at www.cancer.gov. Privacy: http://1.usa.gov/1O5MzXG

Patients with hairy cell leukemia that has relapsed following chemotherapy may be eligible to participate in a new clinical trial at the NIH Clinical Center: https://ccr.cancer.gov/news/article/clinical-trial-tests-combination-therapy-for-relapsed-hairy-cell-leukemia

Results from a new study may explain how astrocytes, a type of brain cell, can drive the spread of cancer to the brain: https://www.cancer.gov/news-events/cancer-currents-blog/2019/brain-metastasis-astrocytes-ppar-gamma

A study led by investigators in NCI's Center for Cancer Research could lead to new combination therapies to treat aggressive tumors, such as those found in pancreatic cancers. https://ccr.cancer.gov/news/article/computational-analysis-leads-to-potential-new-drug-combination-for-pancreatic-cancer

Investigators in NCI's Center for Cancer Research are testing radiotracer imaging to try and identify places in the body where prostate cancer has spread: https://ccr.cancer.gov/news/article/clinical-trial-will-test-radiotracer-imaging-for-high-risk-localized-prostate-cancer

Scientists may have pinpointed the cause of some gastrointestinal stromal tumors (GISTs), a rare cancer, according to a new NCI-funded study. However, the culprit isn’t a harmful genetic mutation, but another type of genetic change, what are called epigenetic alterations: https://www.cancer.gov/news-events/cancer-currents-blog/2019/gist-epigenetic-changes-oncogene-activation

Adding the immunotherapy drug durvalumab (Imfinzi) to standard chemotherapy can prolong survival in some people with previously untreated advanced small cell lung cancer: https://www.cancer.gov/news-events/cancer-currents-blog/2019/small-cell-lung-cancer-durvalumab-improves-survival

Updated guidelines on exercise in those living with cancer and cancer survivors were recently released. In this conversation, Dr. Kathryn Schmitz discusses what these new guidelines mean for doctors, patients, and survivors: https://www.cancer.gov/news-events/cancer-currents-blog/2019/cancer-survivors-exercise-guidelines-schmitz

For some patients with metastatic colorectal cancer, a treatment regimen that consists of three targeted cancer drugs can extend the survival of these individuals: https://www.cancer.gov/news-events/cancer-currents-blog/2019/colorectal-cancer-braf-triplet-targeted-therapy

In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues: https://www.cancer.gov/about-cancer/understanding/what-is-cancer#related-diseases

When your loved one has a rare cancer, it can affect your entire family. Parents, spouses, adult children, or other loved ones often need to handle details of medical care and provide physical and emotional support. Here is information about the many sources of support to help families cope and handle the stress of having a rare cancer: https://www.cancer.gov/pediatric-adult-rare-tumor/support

Finding support when you decide to quit smoking is an important step in creating your plan to quit and stay quit. The following resource talks about all the different ways you can find help when you decide to quit smoking: https://www.cancer.gov/about-cancer/causes-prevention/risk/tobacco/help-quitting-fact-sheet

There is no standard or routine screening test for stomach cancer. However, several tests are used to try and diagnose stomach cancer early, as this summary on stomach cancer screening explains: https://www.cancer.gov/types/stomach/patient/stomach-screening-pdq

Researchers are working to advance our understanding of how to prevent, detect, and treat lung cancer. Here's a summary of recent advances in lung cancer research: https://www.cancer.gov/types/lung/research

Liquid biopsies are tests done on blood samples that could offer a non-invasive alternative to traditional tissue biopsies, as Dr. Shana Kelly explains in this video: https://www.youtube.com/watch?time_continue=1&v=wxJn9M-5YWM

The NCI Community Oncology Research Program (NCORP) is a national NCI-supported network that brings cancer clinical trials and cancer care delivery research studies to people in their communities, as this video explains: https://www.youtube.com/watch?v=OyCFbZYgL3U&feature=youtu.be

A clinical trial at the NIH Clinical Center will test the effectiveness of a monoclonal antibody used immediately before and after surgery for patients with primary pancreatic and bile duct cancer and those who have liver metastasis from colorectal cancer: https://ccr.cancer.gov/news/article/clinical-trial-will-test-new-treatment-to-improve-survival-rates-for-patients-with-operable-gastrointestinal-tumors

Flu-like symptoms (also called flu-like syndrome) are a group of related side effects that may be caused by cancer treatments, such as chemotherapy and immunotherapy: https://www.cancer.gov/about-cancer/treatment/side-effects/flu-symptoms

New results from the TAILORx clinical trial may help some women with early-stage breast cancer make decisions about the best treatments to pursue: https://www.cancer.gov/news-events/cancer-currents-blog/2019/tailorx-breast-cancer-high-recurrence-chemotherapy

Drugs known as PARP inhibitors might benefit women who are newly diagnosed with advanced ovarian cancer, according to results from three clinical trials: https://www.cancer.gov/news-events/cancer-currents-blog/2019/parp-inhibitors-ovarian-cancer-initial-treatment

Investigators in NCI's Center for Cancer Research are leading a new study testing a theory that certain bacteria in the gut may influence the development of a rare liver cancer that usually grows in teens and young adults, fibrolamellar hepatocellular carcinoma: https://ccr.cancer.gov/news/article/clinical-trial-studies-antibiotic-therapy-for-fibrolamellar-hepatocellular-carcinoma-a-rare-liver-cancer

A drug developed for treating Alzheimer’s disease might boost a type of immunotherapy for multiple myeloma, new research suggests: https://www.cancer.gov/news-events/cancer-currents-blog/2019/myeloma-car-t-cell-bcma-alzheimers

Researchers have engineered an oncolytic virus to kill cancer cells and boost the immune response against tumors. In a new study, the virus provided T cells around tumors with a hormone they need for their own cell-killing functions: https://www.cancer.gov/news-events/cancer-currents-blog/2019/oncolytic-virus-improves-immune-cell-metabolism

Genetic changes that cause cancer can be inherited or can arise during a person’s lifetime as a result of errors that occur as cells divide or because of damage to DNA caused by certain environmental exposures: https://www.cancer.gov/about-cancer/understanding/what-is-cancer#how-cancer-arises

Immunotherapy drugs, like all medicines, can cause side effects, including rare complications that, for some patients, may be life threatening: https://www.cancer.gov/news-events/cancer-currents-blog/2019/cancer-immunotherapy-investigating-side-effects

cancer.gov

Cost Can Influence Breast Cancer Surgery Choice

In a recent study, women who were newly diagnosed with breast caner reported taking several factors into account when they decided which types of surgery to receive, including cost.

cancer.gov For some women with breast cancer, cost influenced the type of surgery they choose to get to remove their tumors, a new study finds. However, very few women reported discussing the costs of care with their medical team.

Having a recurrence of cancer can cause patients to experience many emotions. Our free booklet "When Cancer Returns" offers suggestions and information to help people dealing with a recurrence of the disease: https://www.cancer.gov/publications/patient-education/when-cancer-returns.pdf

Researchers are testing tumor-targeting viruses as potential treatments for cancer: https://www.cancer.gov/news-events/cancer-currents-blog/2018/oncolytic-viruses-to-treat-cancer

Cells with mutations or alterations in the BRCA1 gene or the BRCA2 gene may develop additional genetic alterations that can lead to certain types of cancer, including breast cancer: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#what-are-brca1-and-brca2

Liquid biopsies are tests done on blood samples that could offer a non-invasive alternative to traditional tissue biopsies, as Dr. Shana Kelly explains in this video: https://imat.cancer.gov/about-imat/outputs-and-achievements/success-stories/liquid-biopsy-3-magnetic-ranking-cytometry-magrc

Investigators in NCI's Center for Cancer Research are leading a study of a combination therapy to treat aggressive B-cell lymphoma that has spread to the brain and spinal cord: https://ccr.cancer.gov/news/article/clinical-trial-studies-combination-therapy-for-b-cell-lymphoma-that-has-spread-to-the-central-nervous-system

People with leukemia, lymphoma, or multiple myeloma may be eligible to participate in a new clinical trial at the NIH Clinical Center. The study is testing a new approach for using chemotherapy to treat graft-versus-host disease after bone marrow transplantation: https://ccr.cancer.gov/news/article/clinical-trial-tests-chemotherapy-dose-for-graft-versus-host-disease-after-bone-marrow-transplant

The HPV vaccine may provide men with “herd immunity” against oral HPV infections, new research suggests: https://www.cancer.gov/news-events/cancer-currents-blog/2019/men-oral-hpv-infection-vaccine-herd-immunity

How does cancer arise? Genetic changes that cause cancer can be inherited from our parents or they can arise during a person’s lifetime, as our summary explains: https://www.cancer.gov/about-cancer/understanding/what-is-cancer#how-cancer-arises

Targeted therapy is a type of cancer treatment that targets the changes in cancer cells that help them to grow, divide, and spread. Our summary explains: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies

New knowledge about the molecular changes that drive different types of lymphoma has led to is a more nuanced view of these cancers and has suggested potential new treatment strategies for certain patients: https://ccr.cancer.gov/news/milestones-2019/article/sorting-lymphoma-subtypes?utm_source=nciresearchctr&utm_medium=facebook&utm_campaign=milestones&utm_content=Staudt

Patients whose liver cancers responded well to immunotherapy had tumors with less cellular diversity than cancers that were not responsive to this type of therapy: https://ccr.cancer.gov/news/article/diversity-of-liver-cancer-cells-can-impede-tumors-response-to-immunotherapy

What are the signs and symptoms of endometrial cancer? These include unusual vaginal bleeding or pain in the pelvis, as our summary explains: https://www.cancer.gov/types/uterine/patient/endometrial-treatment-pdq

After a diagnosis of breast cancer, men may be more likely to die than women, according to a new study: https://www.cancer.gov/news-events/cancer-currents-blog/2019/male-breast-cancer-higher-mortality

People with inherited diseases of the blood and immune system can now receive treatment at the National Institutes of Health Clinical Center through a new program that brings together experts from many medical specialties and related basic science disciplines: https://www.nih.gov/news-events/news-releases/new-nih-program-provides-comprehensive-treatment-inherited-blood-immune-diseases

The investigational drug selpercatinib may benefit patients with lung cancer whose tumors have alterations in the RET gene, including fusions with other genes: https://www.cancer.gov/news-events/cancer-currents-blog/2019/selpercatinib-lung-cancer-ret-alterations

Four hereditary renal cell, or kidney, cancer syndromes and the genes that cause them have been identified: https://www.cancer.gov/types/kidney/patient/kidney-genetics-pdq#_27

Please join our webinar on the Childhood Cancer Data Initiative on October 8 at 1 pm ET. NCI experts will provide updates on the initiative and answer questions. You can register and submit questions here: https://datascience.cancer.gov/news-events/events/childhood-cancer-data-initiative-webinar

The investigational drug selpercatinib may benefit patients with lung cancer whose tumors have alterations in the RET gene, according to preliminary results from a clinical trial. https://www.cancer.gov/news-events/cancer-currents-blog/2019/selpercatinib-lung-cancer-ret-alterations

For many children with high-risk neuroblastoma, receiving two separate stem cell transplants is more beneficial than receiving one, according to the results of an NCI-supported clinical trial conducted by the Children’s Oncology Group: https://www.cancer.gov/news-events/cancer-currents-blog/2019/high-risk-neuroblastoma-tandem-transplant

NCI researchers are watching human cancer cells travel through the bodies of translucent fish to learn about the factors that drive cancer’s spread through the body: https://ccr.cancer.gov/news/article/tumor-cells-in-transparent-fish-reveal-physical-and-molecular-factors-that-determine-metastasis-sites

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Bethesda, MD
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General information

The National Cancer Institute ( NCI) is the U.S. government’s lead agency for cancer research and is part of the National Institutes of Health (NIH). We welcome your opinion – whether you are a patient, family member, health professional, researcher, or simply an interested member of the public. Reporter and bloggers, please check out our Office of Media Relations on Facebook at http://facebook.com/NCImedia. By commenting on this page you agree to follow NCI's Comment Policy. Comments that do not adhere to this policy may be hidden or removed. Policy: https://www.cancer.gov/policies/comments.

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